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The purpose of the study it to compare the effects of Holy-Comod and Tears Naturale Forte on ocular surface and tear inflammatory mediators in patients after Phaco+IOL.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hylo-Comod | Experimental | The patients used Hylo-Comod eye drop after phaco+IOL in this group. |
|
| Tears Naturale Forte | Experimental | The patients used Tears Naturale Forte eye drop after phaco+IOL in this group. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hylo-Comod eye drop | Drug | The patients were administrated Hylo-Comod eye drop four times a day after Phaco+IOL |
|
| Measure | Description | Time Frame |
|---|---|---|
| scale of Schirmer I test | up to 2 months after surgery | |
| scale of corneal fluorescein staining | up to 2 months after surgery | |
| scale of noninvasive tear breakup time | up to 2 months after surgery | |
| questionnaire of ocular surface disease index | up to 2 months after surgery | |
| scale of central corneal sensitivity | up to 2 months after surgery | |
| scale of tear meniscus height | up to 2 months after surgery | |
| concentration of Interleukin-1α | up to 2 months after surgery | |
| concentration of tumor necrosis factor-α | up to 2 months after surgery | |
| concentration of nerve growth factor | up to 2 months after surgery | |
| concentration of interferon-γ | up to 2 months after surgery | |
| concentration of transforming growth factor-β1 | up to 2 months after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation Between Inflammatory Mediators and Ocular Surface Changes | up to 2 months after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| CHI ZHANG, MD, PhD | Contact | +8613790077756 | mike0946@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Xingwu Zhong, MD, PhD | Zhongshan Ophthalmic Center, Sun Yat-sen University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hainan Eye Hospital, Zhongshan Ophthalmic Center of Sun Yat-sen University | Recruiting | Haikou | Hainan | 570311 | China |
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| ID | Term |
|---|---|
| D014031 | Tobramycin |
| D003907 | Dexamethasone |
| D000078162 | Tobramycin, Dexamethasone Drug Combination |
| C022030 | methylacetylene |
| ID | Term |
|---|---|
| D009328 | Nebramycin |
| D007612 | Kanamycin |
| D000617 | Aminoglycosides |
| D006027 | Glycosides |
| D002241 |
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| Tears Naturale Forte eye drop | Drug | The patients were administrated Tears Naturale Forte eye drop four times a day after Phaco+IOL |
|
|
| concentration of matrix metalloproteinase-9 | up to 2 months after surgery |
| Carbohydrates |
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |
| D004338 | Drug Combinations |
| D004364 | Pharmaceutical Preparations |