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Double-blind, randomized, controlled, cross-over design with 3 test products and one control product.
To evaluate the effect of 4 different flour compositions (guar gum 2% and 4%, chickpea flour 15% and barley flour 2% and 5%) of selected fibres and flours, on post-prandial plasma (PPG) and serum insulin levels in healthy Indian subjects, after the consumption of flat bread made from 100 gram of flour compositions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control (market standard) | Placebo Comparator | 100 g wheat flour (atta) |
|
| High fibre 1 | Active Comparator | 81% wheat flour (atta) + 15% chickpea + 4% guar gum |
|
| High fibre 2 | Active Comparator | 80% wheat flour (atta) + 15% chickpea + 2% guar gum + 3% barley |
|
| High fibre 3 | Active Comparator | 77% wheat flour (atta) + 15% chickpea + 3% guar gum + 5% barley |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Control (market standard) | Other |
| ||
| wheat flour |
| Measure | Description | Time Frame |
|---|---|---|
| Positive incremental area under blood glucose curve | 0-120 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Total area under the serum insulin curve | 0-120 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Cmax glucose | 0-120 minutes | |
| Tmax glucose | 0-120 minutes | |
| Slope to Cmax |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Rakesh Patel, Dr. | Lambda Therapeutic Research Ltd. | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Lambda Therapeutics Research Ltd (LTRL) | Ahmedabad | Near Gujrat High Court, SG Highway, Gota | 380 061 Gujrat | India |
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|
| chickpea flour | Other |
|
| guar gum | Other |
|
| barley | Other |
|
| 0-120 minutes |
| Glucose concentration | 180 minutes |
| Insulin concentration | 180 minutes |
| Total area under the glucose curve | 0-180 minutes |
| Total area under the curve of appetite and mood | 0-120 minutes |
| ID | Term |
|---|---|
| D005433 | Flour |
| C007894 | guar gum |
| ID | Term |
|---|---|
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |
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