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Identify one or more flat bread mixes that produce a reduction in positive incremental area under the curve (iAUC) of post-prandial glucose relative to the control product.
This study was a double-blind, randomised, balanced incomplete block design exploratory study of efficacy, with 11 active treatments compared to a control product in 42 healthy subjects to see if a mix of active ingredients (viscous fibres and flours) lowered the post-prandial glucose (PPG) response in capillary blood (finger prick) over a two and three hours period, relative to the control product. Every subject received the control and 4 out of the 11 treatments on five separate test days.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Placebo Comparator | 100 g high fibre flour |
|
| Active 1 | Active Comparator | 85 g high fibre flour + 15 g legume flour |
|
| Active 2 | Active Comparator | 98 g high fibre flour + 2 g guar gum |
|
| Active 3 | Active Comparator | 88 g high fibre flour + 2 g guar gum + 10 g legume flour |
|
| Active 4 | Active Comparator | 83 g high fibre flour + 2 g guar gum + 15 g legume flour |
|
| Active 5 | Active Comparator | 96 g high fibre flour + 4 g guar gum |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Control | Other | 100 g high fibre flour |
| |
| Active 2 |
| Measure | Description | Time Frame |
|---|---|---|
| Positive incremental area under the curve (iAUC) | 120 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Positive incremental area under the curve (iAUC) | 180 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sarah Hull | Leatherhead Food Research UK | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Leatherhead Food Research UK | Leatherhead | Randalls Road, Surrey | KT22 7RY | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27324141 | Derived | Boers HM, MacAulay K, Murray P, Seijen Ten Hoorn J, Hoogenraad AR, Peters HPF, Vente-Spreeuwenberg MAM, Mela DJ. Efficacy of different fibres and flour mixes in South-Asian flatbreads for reducing post-prandial glucose responses in healthy adults. Eur J Nutr. 2017 Sep;56(6):2049-2060. doi: 10.1007/s00394-016-1242-9. Epub 2016 Jun 21. |
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| ID | Term |
|---|---|
| C078192 | Bc-4 active principle |
| C587932 | pTAC5 protein, Arabidopsis |
| C000627973 | pTAC10 protein, Arabidopsis |
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| Active 6 |
| Active Comparator |
86 g high fibre flour + 4 g guar gum + 10 g legume flour |
|
| Active 7 | Active Comparator | 81 g high fibre flour + 4 g guar gum + 15 g legume flour |
|
| Active 8 | Active Comparator | 94 g high fibre flour + 6 g guar gum |
|
| Active 9 | Active Comparator | 98 g high fibre flour + 2 g konjac mannan |
|
| Active 10 | Active Comparator | 96 g high fibre flour + 4 g konjac mannan |
|
| Active 11 | Active Comparator | 100 g low fibre flour |
|
| Other |
98 g high fibre flour + 2 g guar gum |
|
| Active 3 | Other | 88 g high fibre flour + 2 g guar gum + 10 g legume flour |
|
| Active 4 | Other | 83 g high fibre flour + 2 g guar gum + 15 g legume flour |
|
| Active 5 | Other | 96 g high fibre flour + 4 g guar gum |
|
| Active 6 | Other | 86 g high fibre flour + 4 g guar gum + 10 g legume flour |
|
| Active 7 | Other | 81 g high fibre flour + 4 g guar gum + 15 g legume flour |
|
| Active 8 | Other | 94 g high fibre flour + 6 g guar gum |
|
| Active 9 | Other | 98 g high fibre flour + 2 g konjac mannan |
|
| Active 10 | Other | 96 g high fibre flour + 4 g konjac mannan |
|
| Active 11 | Other | 100 g low fibre flour |
|
| Active 1 | Other | 85 g high fibre flour + 15 g legume flour |
|