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| Name | Class |
|---|---|
| The New Zealand Institute of Plant and Food Research Ltd. | OTHER_GOV |
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The first study of my PhD showed that acute supplementation of berry extracts can modulate cognitive behaviour in healthy adults. There is a growing body of evidence supporting an improvement in memory and learning performance in animal models following the ingestion of flavonoid rich fruits (Shukitt-Hale et al 2008;Spencer 2008; Spencer et al., 2008). However, study 2, showed no effect on any aspects of memory in healthy young adults after supplementation of the berry extracts. It is hypothesised that the lack of behavioural effects on memory of the berry juice in study 2 was because of the cohort used. These healthy adult participants were already performing near to their peak (Salthouse et al., 2009), and unlike study one, participants were not mentally fatigued enough to reveal subtle cognitive benefits.
The aims of the study are to examine if acute supplementation of two berry extracts in an older population can augment memory, attention and executive function. Secondly, the time course of these behavioural effects will be measured by multiple cognitive assessments throughout the day after consumption of the extracts.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Placebo Comparator | Sugar matched control containing no phytochemicals |
|
| Juiced berry drink | Experimental | Cold pressed berry drink standardised to contain 500mg of berry polyphenols |
|
| Powdered berry drink | Experimental | Berry drink made up from a powdered concentrate. each drink will be standardised to contain 500mg of polyphenols |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Berry drink | Dietary Supplement | Cold pressed berry drink standardised to contain 500mg of berry polyphenols |
|
| Measure | Description | Time Frame |
|---|---|---|
| Blood glucose | Change from baseline at 60, 140, 180, 200, 230 and 350 minutes post dose | |
| Blood lactate | Change from baseline at 60, 140, 180, 200, 230 and 350 minutes post dose | |
| Monoamine oxidase B inhibition | Change from baseline at 350 minutes post dose | |
| Cognitive Measures - Memory- Assessed using a computerised cognitive batter. | Change from baseline 60, 150, 240 and 360 minutes post dose | |
| Cognitive Measures - Attention- Assessed using a computerised cognitive batter. | Change from baseline 60, 150, 240 and 360 minutes post dose |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Brain, Performance and Nutrition Research Centre | Newcastle upon Tyne | Newcastle Upon-Tyne | NE18ST | United Kingdom |
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| Label | URL |
|---|---|
| Related Info | View source |
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| Control | Dietary Supplement | Sugar matched control containing berry flavouring and no phytochemicals |
|
| Powdered berry drink | Dietary Supplement | Berry drink made from a powder concentrate standardised to contain 500mg of polyphenols |
|