Study of CS-3150 in Hypertensive Patients With Type 2 Diabetes and Albuminuria

A Study of CS-3150 to Evaluate Efficacy and Safety in Hypertensive Patients With Type 2 Diabetes and Albuminuria.

To examine antihypertensive effect and safety of administration of CS-3150 in combination with ARB or ACE inhibitor in hypertensive patients with type 2 diabetes and albuminuria.

Inclusion Criteria:

• Male and female subjects aged 20 to 80 years at informed consent
• Subjects with type 2 diabetes and albuminuria (urine albumin-to-creatinine ratio ≥ 30, < 1000 mg/g/Cr)
• Subjects with hypertension (Sitting SBP ≥ 140 mmHg, <180 mmHg and Sitting DBP ≥ 80 mmHg, <110 mmHg
• Treatment with an ARB or ACE inhibitor
• eGFR ≥ 30 mL/min/1.73m^2

Exclusion Criteria:

• Secondary hypertension or malignant hypertension
• Type 1 diabetes
• Secondary glucose intolerance
• Diagnosed with non-diabetic nephropathy
• Serum potassium level < 3.5 or ≥ 4.8 mEq/L