Study of CS-3150 in Patients With Severe Hypertension

A Study to Evaluate Efficacy and Safety of CS-3150 in Japanese Patients With Severe Hypertension (Grade III)

To examine antihypertensive effect and safety of administration of CS-3150 in patients with severe hypertension (Grade III).

Inclusion Criteria:

• Male and female subjects aged 20 to 80 years at informed consent
• Subjects with severe hypertension, who do not receive any antihypertensive drugs or receive antihypertensive drug (except for potassium-sparing diuretics) during run-in period (Sitting SBP ≥ 180 mmHg or Sitting DBP ≥ 110 mmHg)

Exclusion Criteria:

• Patients who are suspected hypertensive emergency
• Secondary hypertension or malignant hypertension
• Diabetes mellitus with albuminuria
• Serum potassium level < 3.5 or ≥ 5.1 mEq/L (≥ 4.8 mEq/L if receive RA inhibitor)
• eGFR < 60 mL/min/1.73 m^2.