Hypertrophic Cardiomyopathy Pilot Study

Pilot Observational Case-control Study of the Electrical Heterogeneity in Patients With Hypertrophic Cardiomyopathy and High Arrhythmic Risk

This study evaluates mechanisms of arrhythmogenicity in hypertrophic cardiomyopathy, in comparison to patients with well-understood arrhythmogenic substrate (ischemic cardiomyopathy), as well as to individuals free from arrhythmogenic substrate

Inclusion Criteria:

• Diagnosed HCM
• Documented history of sustained ventricular tachyarrhythmia or resuscitated sudden cardiac arrest
• Maximal left ventricular wall thickness of > 30mm
• Extensive fibrosis on cardiac MRI (>15% of total myocardial volume)
• >7.5%/5-year risk of sudden cardiac death as determined by HCM risk-SCD

Exclusion Criteria:

• age < 18 years
• Pregnancy
• Atrial Fibrillation