The Effect of DPP4 Inhibitor on Vasclular Healing

A Prospective, Multi-center, Randomized, Controlled Study to Evaluate the Effect of DiPeptidyl-Peptidase 4 Inhibitor on Vascular Healing After Biodegradable Polymer Based Sirolimus Eluting Stent Implantation in Diabetic Patients: OCT Study (DIAMOND-OCT)

This study evaluate the effect of dipeptidyl-peptidase 4 inhibitor on vascular healing after biodegradable polymer based sirolimus eluting stent implantation in diabetic pateints.

Inclusion Criteria:

• Non-ST segement elevation acute coronary syndrome

Exclusion Criteria:

• Left main disease
• Known hypersensitivity or contraindication to any of the following medications: Heparin, aspirin, clopidogrel, sirolimus, siptagliptin and statin
• Congestive heart failure (patients with LVEF <30% or cardiogenic shock)
• Uncontrolled myocardial ischemia (repeated chest pain or dyspnea after revascularization)
• Uncontrolled ventricular arrhythmia
• History of malignancy with chemotherapy
• Serious hematologic disease (e.g. CML, MDS)
• Current infectious disease needs antibiotics therapy
• Creatinine level >1.5 mg/dL or dependence on dialysis
• Other severe concurrent illness (e.g. active infection, malignancy).
• Life expectancy of less than one year
• Pregnancy or women with potential childbearing
• Type I DM
• Treatment with insulin
• History of pancreatitis
• Who cannot read the informed consent form (e.g. illiteracy, foreigner)