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| Name | Class |
|---|---|
| University Hospital, Basel, Switzerland | OTHER |
| Basel Institute of Clinical Epidemiology (BICE) | OTHER |
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The aims of the study are twofold. In the cross-sectional approach (Part I), the study will be conducted in an older population to assess the association of physical fitness on different parts of the human vascular bed. In the interventional approach (Part II), it aims to investigate whether and to what extent advanced vascular ageing (AVA) in older subjects with increased cardiovascular risk can be reversed by regular walking- based high intensity interval training.
In the cross-sectional part the investigators analyze physical fitness, vascular health and further outcomes in a healthy older active, a healthy older sedentary and a obese sedentary group with increased cardiovascular risk. The investigators will analyze large and small artery function, physical fitness and activity as well as inflammatory parameters in these three groups. Here the investigators will investigate the influence of physical activity and inflammatory parameters on the vascular health in different beds.
In the intervention part the older sedentary group with increasing cardiovascular risk (OSR) will be randomized in a control and an intervention group. The intervention group will get a high intensity interval training which is walking based and individual adjusted. The control group will get general lifestyle recommendations. After 12 weeks of training OSR group will be tasted again. The aim of the second part is to assess the effect of high intensity interval training on vascular health and inflammatory parameters.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| healthy older active | No Intervention | only cross-sectional | |
| healthy older sedentary | No Intervention | only cross-sectional | |
| older sedentary at risk | Active Comparator | cross-sectional and training or control condition |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Training or control condition | Other | Participants get a 12 week high intensity and walking-based interval training which is adapted to their individual physical fitness level or a general recommendation on physical activity according to European Guidelines. |
| Measure | Description | Time Frame |
|---|---|---|
| Change of pulse wave velocity (m/s) | Measured at local, central and peripheral site | Change from baseline pulse wave velocity at 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change of augmentation index (AIx@75) in % | AIx and AIx@75 will be measured by using the gold standard device for single measurements (SphygmoCor®) | Change from baseline augmentation index at 12 weeks |
| Change of arteriolar to venular diameter ratio (AVR) in µm |
| Measure | Description | Time Frame |
|---|---|---|
| Change of diastolic function parameters (E/A; E/E') | Echocardiography | Change from baseline parameters at 12 weeks |
| Change of autonomic function in heart rate variability (HRV) in beats per minute (bpm) |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bereich Sport- und Bewegungsmedizin, Abteilung Präventive Sportmedizin & Systemphysiologie | Basel | Canton of Basel-City | 4052 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25558034 | Background | Hanssen H, Nussbaumer M, Moor C, Cordes M, Schindler C, Schmidt-Trucksass A. Acute effects of interval versus continuous endurance training on pulse wave reflection in healthy young men. Atherosclerosis. 2015 Feb;238(2):399-406. doi: 10.1016/j.atherosclerosis.2014.12.038. Epub 2014 Dec 23. | |
| 24728623 | Background |
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
| D009765 | Obesity |
| D050197 | Atherosclerosis |
| D004194 | Disease |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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Dynamic and static retinal vessel analyzes will be investigated |
| Change from baseline AVR at 12 weeks |
| Change of physical activity in METs per week | The Freiburger Questionnaire of physical activity and inactivity and an accelerometer for seven days will be used to measure physical activity. | Change from baseline physical activity at 12 weeks |
| Change of physical fitness in VO2max | An individual treadmill ramp test will be used to investigate peak oxygen consumption and maximal heart rate. | Change from baseline VO2max at 12 weeks |
12-lead ECG monitoring
| Change from baseline HRV at 12 weeks |
| Change of serum biomarkers (hs-CRP, IL-6, IL-10, TNF-α) | Blood sampling | Change from baseline serum biomarkers at 12 weeks |
| Change of cognitive Function | Executive function test battery | Change from baseline cognitive function at 12 weeks |
| Nussbaumer M, Donath L, Fischer M, Schafer J, Faude O, Zahner L, Schmidt-Trucksass A, Hanssen H. Effects of acute bouts of endurance exercise on retinal vessel diameters are age and intensity dependent. Age (Dordr). 2014 Jun;36(3):9650. doi: 10.1007/s11357-014-9650-3. Epub 2014 Apr 12. |
| 21392768 | Background | Hanssen H, Nickel T, Drexel V, Hertel G, Emslander I, Sisic Z, Lorang D, Schuster T, Kotliar KE, Pressler A, Schmidt-Trucksass A, Weis M, Halle M. Exercise-induced alterations of retinal vessel diameters and cardiovascular risk reduction in obesity. Atherosclerosis. 2011 Jun;216(2):433-9. doi: 10.1016/j.atherosclerosis.2011.02.009. Epub 2011 Feb 17. |
| 35194110 | Derived | Streese L, Demougin P, Iborra P, Kanitz A, Deiseroth A, Kropfl JM, Schmidt-Trucksass A, Zavolan M, Hanssen H. Untargeted sequencing of circulating microRNAs in a healthy and diseased older population. Sci Rep. 2022 Feb 22;12(1):2991. doi: 10.1038/s41598-022-06956-4. |
| 31551805 | Derived | Deiseroth A, Streese L, Kochli S, Wust RS, Infanger D, Schmidt-Trucksass A, Hanssen H. Exercise and Arterial Stiffness in the Elderly: A Combined Cross-Sectional and Randomized Controlled Trial (EXAMIN AGE). Front Physiol. 2019 Sep 4;10:1119. doi: 10.3389/fphys.2019.01119. eCollection 2019. |
| 31333489 | Derived | Streese L, Kotliar K, Deiseroth A, Infanger D, Vilser W, Hanssen H. Retinal Endothelial Function, Physical Fitness and Cardiovascular Risk: A Diagnostic Challenge. Front Physiol. 2019 Jul 5;10:831. doi: 10.3389/fphys.2019.00831. eCollection 2019. |
| 31323685 | Derived | Streese L, Khan AW, Deiseroth A, Hussain S, Suades R, Tiaden A, Kyburz D, Cosentino F, Hanssen H. High-intensity interval training modulates retinal microvascular phenotype and DNA methylation of p66Shc gene: a randomized controlled trial (EXAMIN AGE). Eur Heart J. 2020 Apr 14;41(15):1514-1519. doi: 10.1093/eurheartj/ehz196. |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D010335 | Pathologic Processes |
| D001519 | Behavior |