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This study examined the efficacy of an integrative cognitive remediation program (REHACOP) to improve cognition, social cognition, clinical symptoms and functional outcome in patients with schizophrenia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Rehacop group | Experimental | Cognitive rehabilitation |
|
| Control group | Active Comparator | Occupational activities |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| REHACOP | Behavioral | REHACOP group consists of 90-minute-long sessions 3 days per week. Specifically, REHACOP group remediation consisted of: Attention unit (4 weeks) training sustained, selective, alternant and divided attention; Memory unit (3 weeks) focusing on visual and verbal learning, recall and recognizing memory; Language unit (3 weeks) including grammar, syntax, vocabulary, verbal fluency, verbal comprehension, abstract language; Executive functions unit (2 weeks) training cognitive planning, proverbs, analogies; and Social cognition unit (1 week) exercising theory of mind, social reasoning and moral dilemmas |
| Measure | Description | Time Frame |
|---|---|---|
| Change in functional competence after receiving cognitive remediation | functional competence was measured with San Diego UCSD Performance-Based Skills Assessment- UPSA | 4 months |
| Change in global functioning after receiving cognitive remediation | global functioning measured with Global Assessment of Functioning (GAF) | 4 months |
| change in verbal memory after receiving cognitive remediation | Verbal memory performance was assessed with the Hopkins Verbal Learning Test-HVLT (Brandt and Benedict 2001) | 4 months |
| change in processing speed after receiving cognitive remediation | Processing speed was assessed with Digit Symbol subtest from Wechsler Adult Intelligence Scale-III (Wechsler 1997) | 4 months |
| Measure | Description | Time Frame |
|---|---|---|
| change in emotion perception after receiving cognitive remediation | emotion perception was assessed with Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT) | 4 months |
| change in clinical symptoms after receiving cognitive remediation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Natalia Ojeda, PhD | University of Deusto | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Deusto | Bilbao | Biskai | 48007 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29525739 | Derived | Pena J, Ibarretxe-Bilbao N, Sanchez P, Uriarte JJ, Elizagarate E, Gutierrez M, Ojeda N. Mechanisms of functional improvement through cognitive rehabilitation in schizophrenia. J Psychiatr Res. 2018 Jun;101:21-27. doi: 10.1016/j.jpsychires.2018.03.002. Epub 2018 Mar 6. | |
| 27868083 | Derived | Pena J, Ibarretxe-Bilbao N, Sanchez P, Iriarte MB, Elizagarate E, Garay MA, Gutierrez M, Iribarren A, Ojeda N. Combining social cognitive treatment, cognitive remediation, and functional skills training in schizophrenia: a randomized controlled trial. NPJ Schizophr. 2016 Nov 9;2:16037. doi: 10.1038/npjschz.2016.37. eCollection 2016. |
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| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
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| Occupational activities | Behavioral | Occupational group activities conducted included drawing, gardening, reading the daily news and constructing using different materials (such as paper or wood). |
|
Clinical symptoms was measured with Positive and Negative Syndrome Scale (PANSS)
| 4 months |
| change in social perception after receiving cognitive remediation | Social perception was assessed with the Social Featuring Recognition Test (SFRT) | 4 months |
| change in theory of mind after receiving cognitive remediation | Theory of mind was assessed with Happe Strange Stories Test | 4 months |