Efficacy of Repyflec Cognitive Remediation Group Training in Schizophrenia

Efficacy of Repyflec Cognitive Remediation Group Training in Cognition, Functional Outcomes and Psychiatric Symptoms of Outpatients With Schizophrenia.

The purpose of this study was to develop an integrative intervention for schizophrenia taking into account previous efficacious therapies. Thus, our aim was to evaluate the efficacy of our cognitive remediation group training: Problem Solving and Cognitive Flexibility training (REPYFLEC), focused to improve neurocognition and functioning in schizophrenia patients. We hypothesized that training executive function and metacognition would allow us to achieve improvements in neurocognition, functioning and psychiatric symptoms of patients with schizophrenia.

Inclusion Criteria:

• Diagnosis of schizophrenia or schizoaffective disorder
• More than 2 years illness duration
• Literate
• Mini Mental Status Examination score over 24
• Global Assessment of Functioning scores between 40 and 70

Exclusion Criteria:

• Current acute illness exacerbation
• Mental Retardation
• Neurological disorder which impairs cognition
• Currently participating in social skills training or cognitive remediation
• Change of antipsychotic medication one month before the trial or during the 40 study weeks
• Diagnosis of alcohol or drug dependence within 6 months of trial commencement.