Periodontal Inflammation and Immunity in Preclinical Rheumatoid Arthritis

Periodontal Inflammation and Immunity in Preclinical Rheumatoid Arthritis

The purpose of this study is to evaluate the association of Rheumatoid Arthritis (RA)-related antibodies and periodontal inflammation in subjects at-risk for Rheumatoid Arthritis. Subjects will undergo periodontal and joint examinations, as well as collection of body fluids to measure Rheumatoid Arthritis-related antibodies.

Inclusion Criteria:

• Rheumatoid Arthritis-antibody positivity (anti-CCP) in the absence of arthritis or
• Early RA <36 months since diagnosis

Exclusion Criteria:

• Pregnancy
• Antibiotic use prior to dental procedures or cleanings
• Wear dentures
• <18 years old