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The aim of this case control study is to explore the possible association between periodontal destruction and serum anti-CCP antibodies in RA patients and healthy subjects.
In patients with RA, the anti-CCP antibody titer seems positively correlated to their periodontal destruction and disease activity in comparison with healthy subjects.
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| Measure | Description | Time Frame |
|---|---|---|
| Serum level of anti-cyclic citrullinated peptide/protein antibody | Lower then 7 Unit/milliliter: negative 7-10 Unit/milliliter: weak positive Higher then 10 Unit/milliliter: positive | Base line |
| Periodontal pocket depth and clinical attachment level | Lower then 4 millimeter: normal Higher then 4 millimeter: diseased/previously diseased | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Serum level of tumor necrotic factor alpha | Recorded in picogram per milliliter | Baseline |
| Serum level of anti-mutated citrullinated vimentin | Recorded in Unit per milliliter |
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Physically healthy persons, especially free of any autoimmune diseases, DM, CVD. No history of periodontal treatment.
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| Name | Affiliation | Role |
|---|---|---|
| Yi-Wen Chen, PhD | Assistant professor | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Taiwan University Hospital | Taipei | 100 | Taiwan |
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| ID | Term |
|---|---|
| D010518 | Periodontitis |
| D001172 | Arthritis, Rheumatoid |
| D001327 | Autoimmune Diseases |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D001168 | Arthritis |
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| Baseline |
| Serum level of interleukin 6 | Recorded in picogram per milliliter | Baseline |
| Serum level of interleukin 17 | Recorded in picogram per milliliter | Baseline |
| D007592 |
| Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
| D003240 | Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D007154 | Immune System Diseases |