Risk of Ectopic Pregnancy and Variation of Luteal Estradiol and Progesterone Levels in IVF

Retrospective Cohort Study of Increased Risk of Ectopic Pregnancy Associated With Marked Variation of Estradiol During the Early Luteal Phase and High Progesterone on hCG Day in IVF

This study evaluates the increased risk of ectopic pregnancy associated with marked variation of estradiol during the early luteal phase and high progesterone on hCG day in IVF.

This is a retrospective cohort study of 578 patients who had no risk of EP (672 fresh transfer IVF cycles) between January 2005 and December 2014. Few studies have reported the relation between hormonal levels and ectopic pregnancy (EP) in IVF. Investigators describe EP incidence according to estradiol (E2) and progesterone (P4) levels on hCG day and seven days later (hCG+7) or their variation between both days.

Inclusion Criteria:

• Normal Fallopian tubes in HSG and /or laparoscopy
• Normal Uterus: Abscence of myomas and Müllerian anomalies .

Exclusion Criteria:

• Previous Ectopic Pregnancy .
• Recurrent Abortion .
• Tubal Factor : pelvic inflammatory disease, Hydrosalpinx
• Previous abdominal surgery (except laparoscopy) .
• Prior Peritonitis
• Smoking (at least 1 cigarette/day) .