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| Name | Class |
|---|---|
| Insel Gruppe AG, University Hospital Bern | OTHER |
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In this study, the investigators pose the question which influence the opioid circuit has on positive valent situations in dreams.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Baseline | No Intervention | reporting of dreams | |
| Naltrexone | Experimental | daily administration of 50mg Naltrexone, reporting of dreams |
|
| Placebo | Placebo Comparator | daily administration of Placebo, reporting of dreams |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Naltrexone | Drug | one week |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| VAS-difference concerning the emotional valence of dreams | Difference between the mean values of emotional valence of dreams reported in the conditions (Naltrexone, Placebo), as captured in VAS [visual analog scales] for every dream | 7 days per condition (Naltrexone, Placebo), intermitted by 14 days of washout |
| Measure | Description | Time Frame |
|---|---|---|
| Semiquantitative score of emotional valence of dreams | Based on computational linguistic analysis of the dreams | 7 days per condition (Baseline, Naltrexone, Placebo), intermitted by 14 days of washout |
| Qualitative score of emotional valence of dreams |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Fred Mast, Prof. Dr. phil. | Head of Cognitive Psychology, Perception and Research Methods, Dean Human Sciences Faculty, Ordinarius, University of Bern | Study Director |
| Claudio L. Bassetti, Prof. Dr. med. | Chairman and Head, Department of Neurology Inselspital, Bern University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Bern | Bern | Canton of Bern | 3012 | Switzerland |
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| ID | Term |
|---|---|
| D009271 | Naltrexone |
| ID | Term |
|---|---|
| D009270 | Naloxone |
| D009019 | Morphinans |
| D053610 | Opiate Alkaloids |
| D000470 | Alkaloids |
| D006571 |
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| Placebo |
| Other |
one week |
|
|
Based on lexical coding of the dreams
| 7 days per condition (Baseline, Naltrexone, Placebo), intermitted by 14 days of washout |
| Heterocyclic Compounds |
| D006572 | Heterocyclic Compounds, Bridged-Ring |
| D006576 | Heterocyclic Compounds, 4 or More Rings |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D010616 | Phenanthrenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D011083 | Polycyclic Compounds |