An fMRI Study of Opioid-related Changes in Neural Activity

An fMRI Study of Opioid-related Changes in Neural Activity

The purpose of the study is to explore the effect of blocking opioids on affiliation-related neural activity.

Inclusion Criteria:

• good health
• between the ages of 18 and 35,
• fluent in English
• right-handed (for the fMRI scan)

Exclusion Criteria:

• Self-reported current or past diagnoses of physical or mental illness.
• Score on the Patient Health Questionnaire (depressive symptoms) above a 13
• Positive urine drug test (for Tetrahydrocannabinol (THC), Opiates, Cocaine, Amphetamine (AMP), and Methamphetamine (mAMP))
• Positive urine pregnancy test
• Use of any prescription medication, except for birth control
• Use of any over-the-counter medications on the day of the fMRI session and 24 hours after the fMRI session
• Self-reported problems with liver functioning, including hepatitis or liver failure
• Difficulty swallowing or taking pills
• BMI greater than 35 or weight greater than 400 lbs
• Claustrophobia
• Nonremovable metal in the body