Continuous NMB in PCAS

Continuous Neuromuscular Blocking Agent for out-of Hospital Cardiac Arrest; Multicenter Randomized Controlled Trial

The main purpose of this study is to test the hypothesis that continuous NMB could improve outcome in cardiac arrest patients treated with therapeutic hypothermia.

Inclusion Criteria:

1. Adult (older than 19)
2. OHCA with sustained ROSC
3. Comatose (i.e., not following commands) following ROSC
4. Undergoing targeted temperature management (TTM)
5. Time of enrollment ≤ 6hrs from ROSC

Exclusion Criteria:

1. Pre-existing dementia, brain injury, or dependence on others for ADLs (CPC > 3)
2. Traumatic etiology for cardiac arrest
3. Protected population (pregnant, prisoner)