Calcium for Out-of-Hospital Cardiac Arrest

Calcium for Out-of-Hospital Cardiac Arrest - A Randomized, Double-Blind, Placebo-Controlled Trial

This is an investigator-initiated, multicenter, randomized, placebo-controlled, parallel group, double-blind, superiority trial of calcium during adult out-of-hospital cardiac arrest. 430 adult patients with out-of-hospital cardiac arrest receiving at least one dose of adrenaline will be enrolled. The primary outcome is sustained return of spontaneous circulation and key secondary outcomes include survival at 30 days and survival at 30 days with a favorable neurological outcome.

Inclusion Criteria:

• Out-of-hospital cardiac arrest
• Age ≥ 18 years
• Received at least one dose of adrenaline

Exclusion Criteria:

• Traumatic cardiac arrest - including drowning and external asphyxia (e.g., hanging, strangulation, or foreign object airway obstruction)
• Known or strongly suspected pregnancy
• Prior enrollment in the trial
• Received adrenaline during cardiac arrest before arrival of prehospital personnel with the study drug
• Clinical indication for calcium administration during the cardiac arrest