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The investigators will use health administrative data to examine the variation of anesthesia type for hip fracture surgery, as well as sources of variation and predictors of variation.
To evaluate the sources of variance in utilization of neuraxial anesthesia the investigators will use multilevel multivariable modeling strategies. This will allow identification of sources of variation (hospital, vs physician, vs patient characteristics), as well as identification of independent predictors of neuraxial use at each of these three levels.
The investigators will also evaluate the independent association of hospital level variation in neuraxial use on our outcomes of interest using multilevel multivariable regression.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Neuraxial anesthesia | Participants in this group will be those who had a spinal or epidural anesthetic without concurrent general anesthesia |
| |
| General anesthesia | Participants in this group will be those who had general anesthesia, including those who had a general plus a concurrent spinal or epidural anesthetic. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Neuraxial anesthesia | Procedure |
|
| |
| Measure | Description | Time Frame |
|---|---|---|
| Number of Participants With All-Cause Mortality at 30-days | Day of surgery to day of death, or up to 30 days, whichever comes first |
| Measure | Description | Time Frame |
|---|---|---|
| Healthcare Costs From the Perspective of the Universal Healthcare System, Using Standardized Methods (Health System Performance Research Network 2013) | Day of surgery to day of death, or 30 days after surgery, whichever comes first |
| Measure | Description | Time Frame |
|---|---|---|
| Hospital Length of Stay | Day of surgery to day of discharge, or up to 365 days, whichever comes first |
Inclusion Criteria:
Exclusion Criteria:
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All Ontario residents aged 66 years or older on the day of their emergency hip fracture surgery.
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| Name | Affiliation | Role |
|---|---|---|
| Daniel McIsaac, MD,MPH,FRCPC | The Ottawa Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ottawa Hospital Research Institute | Ottawa | Ontario | K1Y4E9 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30273269 | Derived | McIsaac DI, Wijeysundera DN, Bryson GL, Huang A, McCartney CJL, van Walraven C. Hospital-, Anesthesiologist-, and Patient-level Variation in Primary Anesthesia Type for Hip Fracture Surgery: A Population-based Cross-sectional Analysis. Anesthesiology. 2018 Dec;129(6):1121-1131. doi: 10.1097/ALN.0000000000002453. |
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| ID | Title | Description |
|---|---|---|
| FG000 | Neuraxial Anesthesia | Participants in this group will be those who had a spinal or epidural anesthetic without concurrent general anesthesia Neuraxial anesthesia |
| FG001 | General Anesthesia | Participants in this group will be those who had general anesthesia, including those who had a general plus a concurrent spinal or epidural anesthetic. General anesthesia |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | Neuraxial Anesthesia | Participants in this group will be those who had a spinal or epidural anesthetic without concurrent general anesthesia Neuraxial anesthesia |
| BG001 | General Anesthesia |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Number of Participants With All-Cause Mortality at 30-days | Data were not collected from the participants in the "General Anesthesia" Arm/Group. Only neuraxial group data available for all cause 30-day mortality. The aim was to measure the association of hospital-level utilization of neuraxial anesthesia, independent of patient-level use, with 30-day survival and length of stay and costs. | Posted | Count of Participants | Participants | Day of surgery to day of death, or up to 30 days, whichever comes first |
|
30 Days
All-Cause Mortality: The occurrence of death due to any cause was reported. No other AEs were collected or monitored.
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Neuraxial Anesthesia | Participants in this group will be those who had a spinal or epidural anesthetic without concurrent general anesthesia Neuraxial anesthesia |
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Health administrative data are not initially collected for research purposes. There are patient-level predictors, hospital-level variables, and anesthesiologist variables that we could not measure directly. Surgeon-specific variables such as preference for neuraxial versus general anesthesia could influence anesthesia decision making and should be considered. Patient-preference should contribute to warranted variation. The generalizability of our findings to other jurisdictions is uncertain.
| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Dr. Daniel McIsaac | The Ottawa Hospital | 613-761-4940 | dmcisaac@toh.ca |
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| ID | Term |
|---|---|
| D006620 | Hip Fractures |
| D003643 | Death |
| ID | Term |
|---|---|
| D005264 | Femoral Fractures |
| D050723 | Fractures, Bone |
| D014947 | Wounds and Injuries |
| D025981 | Hip Injuries |
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| ID | Term |
|---|---|
| D000775 | Anesthesia, Spinal |
| D000767 | Anesthesia, Epidural |
| D000768 | Anesthesia, General |
| ID | Term |
|---|---|
| D000765 | Anesthesia, Conduction |
| D000758 | Anesthesia |
| D000760 | Anesthesia and Analgesia |
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| General anesthesia |
| Procedure |
|
Participants in this group will be those who had general anesthesia, including those who had a general plus a concurrent spinal or epidural anesthetic.
General anesthesia
| BG002 | Total | Total of all reporting groups |
| years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Neighbourhood income quintile | Neighborhood socioeconomic status of the participants is presented as income quintile (income quintile is a measure of neighbourhood socioeconomic status that divides the population into five income groups (from lowest income to highest income)). The scale is from 1-5 (income group quintile 1 (lowest), 2, 3, 4, 5 (highest)). | Median | Inter-Quartile Range | Neighbourhood income quintile |
|
Participants in this group will be those who had general anesthesia, including those who had a general plus a concurrent spinal or epidural anesthetic.
General anesthesia
|
|
| Secondary | Healthcare Costs From the Perspective of the Universal Healthcare System, Using Standardized Methods (Health System Performance Research Network 2013) | Data were not collected from the participants in the "General Anesthesia" Arm/Group. Only neuraxial group data available for healthcare costs. The aim was to measure the association of hospital-level utilization of neuraxial anesthesia, independent of patient-level use, with 30-day survival and length of stay and costs. | Posted | Median | Inter-Quartile Range | Canadian Dollars | Day of surgery to day of death, or 30 days after surgery, whichever comes first |
|
|
|
| Other Pre-specified | Hospital Length of Stay | Data were not collected from the participants in the "General Anesthesia" Arm/Group. Only neuraxial group data available for hospital length of stay The aim was to measure the association of hospital-level utilization of neuraxial anesthesia, independent of patient-level use, with 30-day survival and length of stay and costs. | Posted | Median | Inter-Quartile Range | Days | Day of surgery to day of discharge, or up to 365 days, whichever comes first |
|
|
|
| 9,122 |
| 57,080 |
| 0 |
| 0 |
| 0 |
| 0 |
| EG001 | General Anesthesia | Participants in this group will be those who had general anesthesia, including those who had a general plus a concurrent spinal or epidural anesthetic. General anesthesia | 0 | 0 | 0 | 0 | 0 | 0 |
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| D007869 |
| Leg Injuries |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |