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This study is being done to help understand why some people with an increased amount of central obesity, without gastroesophageal reflux, develop changes to the lining of their esophagus that can potentially lead to esophageal adenocarcinoma (cancer).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Research procedures | Other | Participants enrolled in study will have confocal endomicroscopy, research biopsies, mucosal impedance, and Bravo ambulatory pH capsule performed at the time of clinically indicated endoscopy. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Confocal endomicroscopy | Procedure | Confocal endomicroscopy will be performed during clinically indicated endoscopy. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Compare intercellular space dilation as a marker for apical junction complex integrity in esophageal squamous epithelium by using transmission electron microscopy in those patients with/without gastroesophageal reflux and with/without central obesity. | One year |
| Measure | Description | Time Frame |
|---|---|---|
| Compare paracellular permeability of esophageal squamous epithelium by measuring mucosal impedance and IV fluorescein leak using a confocal laser endomicroscope in those patients with/without gastroesophageal reflux and with/without central obesity. | One year | |
| Compare the prostaglandin E2 level as measured by enzyme immunoassay in esophageal squamous epithelium in those patients with/without gastroesophageal reflux and with/without central obesity. |
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Inclusion Criteria:
Participants who are undergoing clinically indicated upper endoscopy with Bravo ambulatory pH capsule (off reflux medications for 7 days), in the Esophageal Clinic at Mayo Clinic.
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Prasad G Iyer, MD | Mayo Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mayo Clinic | Rochester | Minnesota | 55905 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33955725 | Result | Gibbens YY, Lansing R, Johnson ML, Blevins CH, Katzka DA, Iyer PG. Effects of Central Obesity on Esophageal Epithelial Barrier Function. Am J Gastroenterol. 2021 Jul 1;116(7):1537-1541. doi: 10.14309/ajg.0000000000001196. |
| Label | URL |
|---|---|
| Mayo Clinic Clinical Trials | View source |
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| ID | Term |
|---|---|
| D005764 | Gastroesophageal Reflux |
| D001471 | Barrett Esophagus |
| C562730 | Adenocarcinoma Of Esophagus |
| ID | Term |
|---|---|
| D015154 | Esophageal Motility Disorders |
| D003680 | Deglutition Disorders |
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |
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| Mucosal impedance | Procedure | Mucosal impedance will be performed at the time of clinically indicated endoscopy. |
|
| Research biopsies | Procedure | Research biopsies will be obtained during clinically indicated endoscopy. |
|
| Bravo ambulatory pH monitor | Procedure | Bravo ambulatory pH capsule will be placed during clinically indicated endoscopy. |
|
| One year |
| D004066 | Digestive System Diseases |
| D011230 | Precancerous Conditions |
| D009369 | Neoplasms |