Prognostic and Diagnostic Value of Biomarkers and Cardiac Functional Parameters in Patients With Chronic Heart Failure

Prognostic and Diagnostic Value of Serial Biomarker Measurements, Echocardiographic Techniques and Cardiopulmonary Function Tests in Patients With Chronic Heart Failure.

The study aims to investigate whether disease progression in patients with chronic heart failure (CHF) can be assessed by new biomarkers, and determine their diagnostic value. The study also intends to describe comparison of echocardiography with cardiopulmonary function test in CHF patients, and relating these cardiac functional parameters to clinical outcome.

Inclusion Criteria:

• Age ≥18 years
• with symptoms and signs in NYHA Ⅱ~Ⅳ
• with cardiac structural changes confirmed by echocardiography

Exclusion Criteria:

• with other severe diseases combined and will be alive for less than 12 months
• hard to participate in the investigation or accept the follow-up visits
• pregnant or lactating women
• during the acute phase of ST-elevation acute myocardial infarction, stroke, severe infection and other critical conditions