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This study compares differences in hemodynamic ve ECG parameters of patients undergoing urological or orthopedic surgery under spinal anesthesia. First group will comprise of patients undergoing surgery in the morning hours; thus with a standard fasting duration (8 hours), and the second group will comprise of patients undergoing surgery afternoon; thus having a prolonged fasting duration (>12 hours).
Patients who are scheduled for surgery in surgical wards are routinely fasted after 12am on the day of the surgery regardless of the planned hour of the surgery. This results in a near standard fasting for patients with a planned surgery time in morning hours of the day. However, patients with a planned surgery time in the afternoon hours of the day are fasted more than 12 hours. This situation may not look very important for a healthy young adult but considering that the patient population in a hospital is mostly consisted of sick and elderly people, fasting and associated dehydration may have serious deleterious effects. Our objective is to observe and define these potential deleterious effects with a special focus on cardiovascular system of the patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cohort 1- Morning Surgery | Patients' who are scheduled for surgery under spinal anesthesia with bupivacaine in morning hours (until 12pm) will be included in this cohort. Since all patients are ordered to stop oral ingestion by 12am at the day of the surgery, patients in this cohort will be exposed to a preoperative fasting for 8 hours |
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| Cohort 2- Afternoon Surgery | Patients' who are scheduled for surgery under spinal anesthesia with bupivacaine in afternoon hours (after 12pm) will be included in this cohort. Since all patients are ordered to stop oral ingestion by 12am at the day of the surgery, patients in this cohort will be exposed to a preoperative fasting for more than 12 hours |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Preoperative Fasting for 8 hours | Other | Patients will be exposed to preoperative fasting |
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| Measure | Description | Time Frame |
|---|---|---|
| Evidence of ischemic changes in 12 lead electrocardiogram | Changes in ST and T waves compared to a baseline preoperative ECG will be monitored and recorded right after spinal block is placed, and at 1st, 2nd, 5th and 15th minutes after spinal injection | Immediately after, 1, 2, 5 and 15 minutes after injection of bupivacaine for spinal block |
| Measure | Description | Time Frame |
|---|---|---|
| Evidence of hypotension confirmed by non-invasive blood pressure measurement | Changes in mean arterial blood pressure will be monitored and a decrease of 10% from baseline mean arterial blood pressure will be recorded as hypotension right after, 1, 2, 5 and 15 minutes after injection of bupivacaine for spinal block spinal block is placed | Immediately after, 1, 2, 5 and 15 minutes after injection of bupivacaine for spinal block |
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Inclusion Criteria:
Exclusion Criteria:
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Patients over the age of 60 who scheduled for urological or orthopedic surgery under spinal anesthesia
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| Name | Affiliation | Role |
|---|---|---|
| Oguzhan Yeniay, MD | Izmir Bozyaka Training and Research Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Izmir Bozyaka Training and Research Hospital | Izmir | İzmir | 35170 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D005215 | Fasting |
| D007431 | Intraoperative Complications |
| D007511 | Ischemia |
| ID | Term |
|---|---|
| D005247 | Feeding Behavior |
| D001519 | Behavior |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D000775 | Anesthesia, Spinal |
| D002045 | Bupivacaine |
| ID | Term |
|---|---|
| D000765 | Anesthesia, Conduction |
| D000758 | Anesthesia |
| D000760 | Anesthesia and Analgesia |
| D000813 | Anilides |
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| Preoperative Fasting for more than 12 hours | Other | Patients will be exposed to preoperative fasting |
|
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| Spinal Anesthesia with Bupivacaine | Drug | Spinal Anesthesia with heavy bupivacaine 0.5% is provided. |
|
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| Evidence of hypertension confirmed by non-invasive blood pressure measurement | Changes in mean arterial blood pressure will be monitored and an increase of 10% from baseline mean arterial blood pressure will be recorded as hypertension right after, 1, 2, 5 and 15 minutes after injection of bupivacaine for spinal block | Immediately after, 1, 2, 5 and 15 minutes after injection of bupivacaine for spinal block |
| Evidence of hypoxia confirmed by peripheral oxygen saturation probe | Peripheral oxygen saturation will be continuously monitored and any value less than 90% will be recorded right after spinal block is placed, at first, second, fifth minutes and at 15th minute | Immediately after, 1, 2, 5 and 15 minutes after injection of bupivacaine for spinal block |
| Evidence of tachycardia in 12 lead electrocardiogram | A heart rate equal to / higher than 100 will be recorded right after spinal block is placed, at first, second, fifth minutes and again at 15th minute | Immediately after, 1, 2, 5 and 15 minutes after injection of bupivacaine for spinal block |
| Evidence of bradycardia in 12-lead electrocardiogram | A heart rate equal to / less than 50 will be recorded right after spinal block is placed, at first, second, fifth minutes and again at 15th minute | Immediately after, 1, 2, 5 and 15 minutes after injection of bupivacaine for spinal block |
| D000577 |
| Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |