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The goal of this research study is to examine whether an intervention to increase physical activity using a body-worn sensor affects cognitive (thinking) processes.
The overall duration of participation in this research study is approximately 4 months. During this time, three study visits will be required. The first visit is for informed consent and screening, the second visit is for baseline fitness and cognitive testing, and the third visit is for follow-up fitness and cognitive testing after a 12-week physical activity monitoring program. Participants will be randomized to one of two study arms, a physical activity monitoring arm and a flexibility and balance arm. Both study arms involve wearing a physical activity sensor and monitoring physical activity for a duration of 12 weeks.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Physical activity monitoring | Experimental | Participants will wear a physical activity sensor on the hip or waist with a belt. They will be instructed to increase their physical activity level to at least 150 min of moderate-intensity physical activity per week. They will be asked to follow guidelines in the "Go4Life" brochure, website, and/or videos by the National Institute on Aging. Participants will receive weekly phone calls to monitor their progress, to provide feedback, and to suggest example exercises. |
|
| Flexibility and balance | Active Comparator | Participants will wear a physical activity sensor on the hip or waist with a belt. They will be instructed to increase their balance and flexibility over the 12 week period of the intervention. They will be asked to follow guidelines in the "Go4Life" brochure, website, and/or videos by the National Institute on Aging. Participants will receive weekly phone calls to monitor their progress, to provide feedback, and to suggest example exercises. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Physical Activity | Behavioral | Trainer-guided at-home behavioral intervention |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cognition | Change in cognitive task performance post-intervention compared to baseline | 80-90 minutes |
| Aerobic Fitness | Change aerobic fitness measured with treadmill test post-intervention | 30 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Functional fitness: Five Times Sit to Stand | Change in performance in the Five Times Sit to Stand test post-intervention | 10 min |
| Functional fitness: Timed Get Up and Go | Change in performance in the Timed Get Up and Go test post-intervention compared to baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Gait: step and stride time | Change in step and stride time over 12 weeks | 12 weeks |
| Gait: stride time variability | Change in stride time variability over 12 weeks |
Inclusion Criteria:
Exclusion Criteria:
Poor vision that cannot be corrected with glasses or contact lenses
Presence of an acute infection
Diagnosis of kidney failure
Diagnosis of liver disease
Diagnosis of thyrotoxicosis/hyperthyroidism
Diagnosis of cancer
Past or present conditions that affect cognitive functioning:
Past or present conditions that are counter indicators for participation in cardio-respiratory fitness assessment and moderate-intensity physical activity:
Obesity
Prescription medication or other drugs that treat heart, lung, or circulatory conditions (e.g. beta blockers, bronchodilators, etc.)
Prescription medication or other drugs that affect chemicals in the brain (e.g. antidepressants, anxiolytics, etc.)
Implanted medical devices, such as a pacemaker or defibrillator
Unavailable for the approx. 4-month duration of the study
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| Name | Affiliation | Role |
|---|---|---|
| Karin Schon, Ph.D. | Boston University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Boston University School of Medicine | Boston | Massachusetts | 02118 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33325614 | Derived | Kern KL, Storer TW, Schon K. Cardiorespiratory fitness, hippocampal subfield volumes, and mnemonic discrimination task performance in aging. Hum Brain Mapp. 2021 Mar;42(4):871-892. doi: 10.1002/hbm.25259. Epub 2020 Dec 16. |
| Label | URL |
|---|---|
| Brain Plasticity and Neuroimaging Laboratory at Boston University | View source |
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| ID | Term |
|---|---|
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| 10 min |
| Functional fitness: Flexibility | Change in performance in the Sit and Reach test post-intervention | 10 min |
| Physical activity | Greater overall moderate-intensity physical activity time and step count and lower sedentary time in the physical activity monitoring than the flexibility and balance group | 12 weeks |
| 12 weeks |
| Gait: gait symmetry | Change in gait symmetry over 12 weeks | 12 weeks |