Insulin Sensitivity and Secretion During Pregnancy and Post Partum in Women With Gestational Diabetes.

Botnia Clamp in Women Before, Immediately After Delivery and 6 Months Post Partum.

Aim of the study:

To define insulin requirement during pregnancy and to identify the rapid changes in insulin sensitivity around parturition and the first 6 months post partum. Such knowledge would be clinically useful and markedly improve insulin treatment before and after parturition for women with type 1 diabetes and serve to identify the best possible timing of testing women with gestational diabetes mellitus (GDM) for the development of type 2 diabetes post partum.

Method:

Botnia clamp in women before, immediately after delivery and 6 months post partum. The investigators will compare 20 women with GDM in late pregnancy, day 15 post partum and 6 months post partum with 20 normal women investigated at the same time points. In addition the investigators will collect feces samples from the mother and baby in order to determine microbiota.

Perspectives:

Diabetes is a common condition with important implications for pregnancy outcome and long-term morbidity for mother and offspring. Accordingly, tailoring the best treatment is expected to have beneficial consequences both for the pregnant women and the future generation.

Inclusion Criteria:

• Written consent before study start.
• Pregnant.
• GDM for the GDM group.
• No diabetes for the control group.

Exclusion Criteria:

• Women with multiple pregnancy.
• New pregnancy before all three examinations has been done.
• Severe, debilitating, concurrent diseases.
• Serious or intolerable adverse reactions associated with the studies.