Not provided
Not provided
Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| 2-APF-2025-1678-A-N | Other Grant/Funding Number | BreakthroughT1D |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Northwestern Memorial Hospital | OTHER |
Not provided
Not provided
Not provided
Not provided
The investigators want to learn how the body's response to insulin changes during pregnancy in people with Type 1 Diabetes.
In this study, the investigators will look at information from people who used a Dexcom continuous glucose monitor (CGM) and a Tandem insulin pump while they were pregnant. Participants will fill out an online survey and agree to share their device data. The investigators will use this information to see how insulin sensitivity changes from three months before pregnancy to six months after the baby is born.
The aim of this retrospective observational study is to collect continuous glucose monitor (CGM) and insulin pump data from pregnant individuals with Type 1 Diabetes, from 3 months before conception to 6 months after delivery. This data will be used to estimate how insulin sensitivity (IS) changes across gestation, with the goal of better understanding glucose-insulin dynamics during pregnancy and develop algorithms for adapting insulin administration across gestational ages.
Participants will complete an online survey where they will provide their insulin pump serial number, date of delivery, gestational week at delivery, date of last menstrual cycle (if known), and other optional demographic information. The study team will use this information to retrieve participants' CGM and insulin infusion data from 3 months before conception to 6 months after delivery.
Up to 200 participants will be screened, with the goal of reaching 100 screened participants.
Not provided
Not provided
Not provided
Not provided
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Percent Time in Target Range | Percentage of time blood glucose was 70mg/dL and 180mg/dL as per CGM | Assessed every 2 weeks from 4 weeks pre-conception to 6 months post partum |
| Measure | Description | Time Frame |
|---|---|---|
| Percent Time Below Range | Percentage of time blood glucose was below 70mg/dL as per CGM | Assessed every 2 weeks from 4 weeks pre-conception to 6 months post partum |
| Percent Time Above Range | Percentage of time blood glucose was above 180 mg/dl as per CGM |
Not provided
Inclusion Criteria:
Not provided
Not provided
Not provided
Adult individuals with T1D who received pregnancy care within the last 8 years in one of the participating sites: UVA Health (Charlottesville, VA), Northwestern Memorial Hospital (Chicago, IL).
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Northwestern Memorial Hospital | Chicago | Illinois | 60611 | United States | ||
| UVA Health |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D003922 | Diabetes Mellitus, Type 1 |
| D003920 | Diabetes Mellitus |
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
| Assessed every 2 weeks from 4 weeks pre-conception to 6 months post partum |
| Charlottesville |
| Virginia |
| 22903 |
| United States |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D006946 | Hyperinsulinism |