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| Name | Class |
|---|---|
| University of Central Florida | OTHER |
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The study will determine whether acute ingestion of a probiotic combined with beta-hydroxy-beta-methylbutyrate (HMB) can enhance immune and digestive function in soldiers during 8-weeks of advanced infantry training.
Up to sixty soldiers from an elite infantry unit will perform a parallel design investigation. Soldiers will be randomly assigned to one of four groups. Group 1 will consume the probiotic plus HMB, group 2 will consume HMB only, group 3 will consume only the probiotic, and group 4 will consume only placebo. All four groups will be garrisoned together, eat the same meals, and perform the same activity. All groups will be tested before as well as after an 8-week advanced infantry training program. During each testing session resting blood samples will be obtained to assess cytokine, inflammatory, and muscle damage markers. Additionally, questionnaires will be used to determine digestive health. Anthropometric, performance, and muscle volume measures will also be assessed prior to and immediately following the supplementation and training protocol.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | Placebo capsules similar to the experimental treatments. |
|
| HMB | Experimental | HMB capsules providing 3 g of calcium HMB per day. |
|
| HMB + BC30 | Experimental | Capsules providing 3 g calcium HMB per day plus Bacillus Coagulans GBI-30, 6086 (BC30) mixed in water. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo | Dietary Supplement | Placebo capsules similar to the experimental treatments. |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Maintenance of Immune function | Immune function assessed by blood biochemical analysis (ELISA). | 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Maintenance of Digestive Function | Digestive function assessed by questionnaire. | 8 Weeks |
| Maintenance of Muscle Volume | Muscle volume will be assessed using a 3.0 Tesla whole-body imager (cubic centimeter) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jay R Hoffman, PhD | University of Cenral Florida | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Israel | Beersheva | Israel |
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| HMB |
| Dietary Supplement |
Capsules containing calcium HMB. |
|
| BC30 | Dietary Supplement | Bacillus Coagulans GBI-30, 6086 (BC30) mixed in water. |
|
| 8 Weeks |