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| Name | Class |
|---|---|
| Iowa State University | OTHER |
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The proposed study will test efficacy of HMB in free acid gel to decrease muscle damage, diminish inflammatory response, and improve muscle strength recovery following an acute exercise stress. HMB in a free acid gel or in CaHMB capsule form will be administered as either a single dose before a bout of acute exercise or in multiple doses (one before and three daily doses for the 4 days following the acute exercise). We hypothesize that HMB in free acid gel will result in less muscle damage, diminished inflammatory response, and improved muscle strength recovery than either a placebo or CaHMB treatment following a bout of acute eccentric exercise. Our endpoints will include measurements of: (1) markers for muscle damage (CPK and LDH); (2) indicators of inflammation (CRP, TNF-α, IL-6, IL-1ra and IL-18); and (3) muscle strength recovery and soreness.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | Oral Placebo capsule and one placebo gel dosage given 30 min prior to the acute exercise session. A placebo capsule and placebo gel dosage are then administered 3 times daily during the remainder of the study. |
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| CaHMB Pre | Experimental | Oral CaHMB capsule and one placebo gel dosage given 30 min prior to the acute exercise session. A placebo capsule and placebo gel dosage are then administered 3 times daily during the remainder of the study. |
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| CaHMB Pre and Post | Experimental | Oral CaHMB capsule and one placebo gel dosage given 30 min prior to the acute exercise session. A CaHMB capsule and placebo gel dosage are are then administered 3 times daily during the remainder of the study. |
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| HMB Free Acid Gel Pre | Experimental | Oral placebo capsule and one HMB free acid gel dosage given 30 min prior to the acute exercise session. A placebo capsule and placebo gel dosage are then administered 3 times daily during the remainder of the study. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CaHMB | Dietary Supplement | CaHMB capsules with each capsule containing 0.8 g of HMB |
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| Measure | Description | Time Frame |
|---|---|---|
| Decrease in muscle damage and inflammation | Serum analysis for markers of muscle damage (CPK) and inflammation (IL-6, IL-18, IL1ra, TNF-a, CRP) will be measured at 24, 48, 72, and 96 h post exercise bout | 4 days post eccentric exercise bout |
| Measure | Description | Time Frame |
|---|---|---|
| Improvement in strength recovery and decrease in soreness | Muscle strength recovery and soreness will be measured at 24, 48, 72, and 96 h post exercise bout. | 4 days post eccentric exercise bout |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| John A Rathmacher, PhD | Metabolic Technologies Inc. | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Iowa State University | Ames | Iowa | 50010 | United States |
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| ID | Term |
|---|---|
| D018979 | Myositis, Inclusion Body |
| ID | Term |
|---|---|
| D009220 | Myositis |
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
| D009468 | Neuromuscular Diseases |
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| HMB Free Acid Gel Pre and Post | Experimental | Oral placebo capsule and one HMB free acid gel dosage given 30 min prior to the acute exercise session. A placebo capsule and HMB free acid gel dosage are then administered 3 times daily during the remainder of the study. |
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| HMB Free Acid Gel | Dietary Supplement | HMB Free acid in a gel form with each dose supplying 0.8 g of HMB free acid |
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| Placebo | Dietary Supplement | Placebo capsules similar in size and color to the CaHMB capsules used in the study |
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| Placebo Gel Dosage | Dietary Supplement | A corn syrup based placebo with flavoring and taste similar to the HMB Free Acid Gel |
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| D009422 |
| Nervous System Diseases |