Anthocyanin Dose-escalation Study in Healthy Young Adults

Anthocyanin Dose-escalation Study in Healthy Young Adults: A CONSORT-compliant, Randomized, Controlled Trial

Anthocyanins are naturally existing, polyphenolic compounds found in the vacuolar sap of the epidermal tissues of flowers and fruits, with a pink, red, blue, or purple color. Recently, study of anthocyanin pigments has drawn more and more interest since several epidemiological studies have demonstrated their health-promoting properties, such as reducing lipid accumulation and decreasing oxidative stress and inflammation. Nevertheless, there is a clear need for advancing understanding with regard to effective amounts of intake for these phytochemicals. The aim of this study was to investigate the efficacy and pharmacokinetics of anthocyanin in healthy volunteers.

Inclusion Criteria:

• Blood test, liver function test, renal function test are normal;
• Blood lipids, cardiac function are normal;
• 18.5<BMI<23.9;
• Regular dietary, seldomly eating outside;
• Stable condition of body weight in recent 3 months

Exclusion Criteria:

• > 140 grams of alcohol/week for male and >70 grams of alcohol/week for female, smoking regularly;
• Known diagnosis of acute diseases or chronic diseases in recent 1 month;
• Be planning to be pregnant in a year, or being pregnant and lactation.