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Helicobacter pylori eradication (H. pylori) rates with clarithromycin-based triple therapy are declining, and an alternative strategy is needed urgently. The investigators sought to compare the efficacy of pretreatment antimicrobial susceptibility-guided vs. clarithromycin-based triple therapy vs. concomitant therapy for H. pylori eradication in a region with high rates of multiple drug resistance.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Susceptibility-guided group | Active Comparator | Drugs according to antimicrobial susceptibility-guided treatment |
|
| triple therapy group | Sham Comparator | Drugs - Pantoloc 40mg, PO, BID, 1wk Amoxacillin 1g, PO, BID, 1wk Clarithromycin 500mg, PO, BID, 1wk |
|
| concomitant therapy group | Sham Comparator | Drugs - Pantoloc 40mg, PO, BID, 1wk Amoxacillin 1g, PO, BID, 1wk Clarithromycin 500mg, PO, BID, 1wk Metronidazole 500mg, PO, BID, 1wk |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| eradication of Helicobacter pylori | Drug | clarithromycin-based triple therapy Pantoloc 40mg, PO, BID, 1wk Amoxacillin 1g, PO, BID, 1wk Clarithromycin 500mg, PO, BID, 1wk
|
| Measure | Description | Time Frame |
|---|---|---|
| eradication rate of Helicobacter pylori | the H. pylori status was checked 4 weeks aft er the end of treatment using the 13 C-urea breath test. |
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Inclusion Criteria:
1. positive results of rapid urease test
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gangnam Severance Hospital | Recruiting | Seoul | 135720 | South Korea |
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