The Effect of Anesthetics Agents on Vascular Injury and Level of Syndecan-1 During Knee Surgery

The Effect of Anesthetics Agents on Vascular Injury and Level of Syndecan-1 During Knee Surgery

Ischeic reperfusion injury lead to a cellular dyfunction and increase in soluble glycocalyx of blood flow. syndecan-1 was a marker of glycocalyx.

The purpose of this study is to prove the variation of level of serum syndecan-1 between preoperative and postoperative period.

The patients were allocated randomly to receive propofol or desflurane. Also, a total of 6ml of blood sample was obtained for total 6 times in consecutive order.

1. Preoperation (immediate before anesthesia induction)
2. Immediate before tourniquet off
3. 5 min after tourniquet off
4. PACU
5. postoperative 6 hours
6. postoperative 24 hours

Serum in blood will be obtained and level of serum cytokine will be evaluated by enzyme-linked immunosorbent assay

Inclusion Criteria:

• patients who was planned to undergo knee surgery.

Exclusion Criteria:

• age < 20 years old
• history of previous cancer
• history of previous peripheral vascular disease
• Emergency surgery