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Due to the heterogeneity in the first group.
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Aim of the study is to assess the effects of abruptly increased afterload on left ventricular contractility and relaxation in patients with heart failure with preserved ejection fraction (HFPEF), patients with heart failure with reduced ejection fraction (HFREF), and patients without HFPEF or HFREF.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HFPEF | Experimental | Patient with heart failure with preserved ejection fraction (HFPEF) |
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| HFREF | Experimental | Patient with heart failure with reduced ejection fraction (HFREF) |
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| No HFPEF/HFREF | Active Comparator | Patient without heart failure with preserved ejection fraction (HFPEF) or heart failure with reduced ejection fraction (HFREF) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Conductance catheter | Device | Continuous online measurements of left ventricular pressure and volume using conductance catheters |
|
| Measure | Description | Time Frame |
|---|---|---|
| Hemodynamic parameter 1: Changes in contractility assessed by the end-systolic pressure-volume relationship | Changes in contractility after handgrip exercise assessed by the end-systolic pressure-volume relationship | Day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Hemodynamic parameter 2: Changes in contractility assessed by the peak power index | Changes in contractility after handgrip exercise assessed by the peak power index | Day 1 |
| Hemodynamic parameter 3: Changes in relaxation assessed by the relaxation constant "tau" |
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Inclusion Criteria:
AND
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universitätsklinikum Schleswig-Holstein | Lübeck | Schleswig-Holstein | 23538 | Germany |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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Changes in relaxation after handgrip exercise assessed by the relaxation constant "tau" |
| Day 1 |
| Functional parameter: Changes in ejection fraction | Changes in ejection fraction after handgrip exercise assessed by echocardiography | Day 1 |