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| Name | Class |
|---|---|
| University Hospital Tuebingen | OTHER |
| University Hospital Muenster | OTHER |
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In patients with heart failure and preserved ejection fraction (HFpEF) right ventricular (RV) systolic and diastolic dysfunction are prognostically and functionally relevant factors but have mechanistically been neglected so far. In the present study alterations of intrinsic RV (systolic and diastolic) function, as assessed by invasive pressure volume loops, are examined in relation to tissue alterations on myocardial level and to the degree of RV afterload (pulmonary hypertension). Study aim is to gain insights into mechanisms contributing to the development of RV dysfunction and potentially identify new therapeutic targets.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HFpEF with pulmonary hypertension | Invasively diagnosed HFpEF and pulmonary hypertension according to current guidelines |
| |
| HFpEF without pulmonary hypertension | Invasively diagnosed HFpEF without pulmonary hypertension according to current guidelines |
| |
| Patients without HFpEF | Patients without invasive evidence of HFpEF |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Invasive hemodynamics and myocardial biopsies | Diagnostic Test | Invasive hemodynamic characterization (biventricular pressure volume loop assessment) and biventricular myocardial biopsies |
| Measure | Description | Time Frame |
|---|---|---|
| Right ventricular systolic and diastolic function | Assessed with pressure volume loops analysis | Baseline |
| Biventricular myocardial fibrosis | Assessed with histopathology | Baseline |
| Phosphorylation of structural myocardial proteins | Assessed on myocardial biopsy specimen | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Functional capacity | 6-Minute Walk Test / Spiroergometry | Baseline |
| Myocardial fibrosis on cardiac magnetic resonance | Baseline |
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HFpEF
Inclusion Criteria:
No Heart Failure
Inclusion Criteria:
Exclusion Criteria:
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outpatient general cardiology clinic
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Heart Center Leipzig at Leipzig University | Recruiting | Leipzig | Saxony | 04289 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29449367 | Result | Rommel KP, von Roeder M, Oberueck C, Latuscynski K, Besler C, Blazek S, Stiermaier T, Fengler K, Adams V, Sandri M, Linke A, Schuler G, Thiele H, Lurz P. Load-Independent Systolic and Diastolic Right Ventricular Function in Heart Failure With Preserved Ejection Fraction as Assessed by Resting and Handgrip Exercise Pressure-Volume Loops. Circ Heart Fail. 2018 Feb;11(2):e004121. doi: 10.1161/CIRCHEARTFAILURE.117.004121. | |
| 31053957 |
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Biventricular myocardial tissue samples. Peripheral blood samples.
| Result |
| von Roeder M, Kowallick JT, Rommel KP, Blazek S, Besler C, Fengler K, Lotz J, Hasenfuss G, Lucke C, Gutberlet M, Thiele H, Schuster A, Lurz P. Right atrial-right ventricular coupling in heart failure with preserved ejection fraction. Clin Res Cardiol. 2020 Jan;109(1):54-66. doi: 10.1007/s00392-019-01484-0. Epub 2019 May 3. |