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| Name | Class |
|---|---|
| Norwegian University of Science and Technology | OTHER |
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Acute aerobic exercise improves affective stats in patients with mental illnesses. Brain derived neurotropic factor (BDNF) may be a biological mechanism that contributes to the affective benefits. The magnitude of the increase of serum BDNF might be exercise intensity dependent, but no study has compared low high-aerobic-intensity training at 90-95 % of the maximal heart rate (HRmax) with long-slow-distance training at 70 % of the HRmax in patients with depression.
The aim of this study is to compare changes in serum BDNF levels after high-aerobic-intensity training and long-slow-distance training in a intra-individual design in patients suffering from depression. The results will give indications of a possible difference in BDNF response between aerobic intensities and may be uses as pilot data for calculating sample size.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise | Experimental | Acute High aerobic intensity training (HIT) and long slow distance training (LSD) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High aerobic intensity training (HIT) | Behavioral | One training session, high aerobic intensity training (HIT) at 90-95 % of the maximal heart rate (HRmax) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in serum brain derived neurotropic factor (BDNF) | To measure serum BDNF levels, blood samples will be taken before and after each workout session. | 15 minutes before exercise to 5> minutes after exercise. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in affective symptoms | The positive and negative affect schedule (PANAS) . | 15 minutes before exercise to 15> minutes after exercise. |
| Change in state of anxiety. | A short form of state trait anxiety inventory for adults (STAI) is used to detect their state of anxiety. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Pål Sandvik, MD | St.Olavs University Hospital, Østmarka | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| St.Olavs university Hospital, Departement of Østmarka | Trondheim | Norway |
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| ID | Term |
|---|---|
| D003866 | Depressive Disorder |
| D003865 | Depressive Disorder, Major |
| ID | Term |
|---|---|
| D019964 | Mood Disorders |
| D001523 | Mental Disorders |
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| Long slow distance training (LSD) | Behavioral | One training session, long slow distance training (LSD) at 70 % of the HRmax |
|
| 15 minutes before exercise and 15> minutes after exercise. |
| Change in subjective exercise experience | The Subjective exercise experience scale (SEES). | 15 minutes before exercise to 15> minutes after exercise. |
| Maximal oxygen uptake | Baseline |
| Maximal Heart rate | Baseline |