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The study aimed to evaluate the use of exercise as a complementary strategy to treat severe major depression in inpatients.
Hypothesis: Exercise can be used as a safe and efficacious complimentary strategy in severe depressed inpatients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise | Experimental | Aerobic Exercise, 3 times peer week, A dose of 16.5 kcal/kg weight peer week. |
|
| Control | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise | Other |
|
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| Measure | Description | Time Frame |
|---|---|---|
| Depressive symptoms | Hamilton 17 for depression | 2 weeks of hospitalization (14 days) |
| Measure | Description | Time Frame |
|---|---|---|
| Quality of Life | WHOQOL-BREF | Baseline, after 2 weeks of hospitalization and at discharge (participants will be followed for the duration of hospital stay, an expected average of 3 weeks) |
| Brain-Derived Neurotrophic Factor(BDNF) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Felipe B Schuch, MSc | HCPA | Principal Investigator |
| Marcelo PA Fleck, PhD | HCPA | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital de Clincas de Porto Alegre | Porto Alegre | Rio Grande do Sul | 90035-903 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21616540 | Result | Schuch FB, Vasconcelos-Moreno MP, Borowsky C, Fleck MP. Exercise and severe depression: preliminary results of an add-on study. J Affect Disord. 2011 Oct;133(3):615-8. doi: 10.1016/j.jad.2011.04.030. Epub 2011 May 25. | |
| 23565097 | Result | Schuch FB, de Almeida Fleck MP. Is Exercise an Efficacious Treatment for Depression? A Comment upon Recent Negative Findings. Front Psychiatry. 2013 Apr 2;4:20. doi: 10.3389/fpsyt.2013.00020. eCollection 2013. No abstract available. |
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| ID | Term |
|---|---|
| D003863 | Depression |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| Baseline, after 2 weeks of hospitalization and at discharge (participants will be followed for the duration of hospital stay, an expected average of 3 weeks) |
| Thiobarbituric acid reactive substances(TBARS) | Baseline, after 2 weeks of hospitalization and at discharge (participants will be followed for the duration of hospital stay, an expected average of 3 weeks) |
| Depressive symptoms at discharge (participants will be followed for the duration of hospital stay, an expected average of 3 weeks) | Hamilton Scores at discharge | Discharge |