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This study evaluates the use of Rhodiola rosea in the treatment of Attention Deficit/Hyperactivity Disorder (ADHD) in adults. Half of participants will receive Rhodiola rosea, while the other half will receive placebo.
Rhodiola rosea is an herbal medicine used for centuries in various medical conditions. Many randomized controlled trials have evaluated its usefulness in stress and fatigue. There were benefits in attention in some of these studies. Mild side effects and beneficial antioxidant properties make reasonable an assessment of its potential benefits in adults with ADHD. To our knowledge, Rhodiola rosea was never studied in ADHD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Rhodiola | Experimental | Rhodiola rosea 200mg up to four times a day for 28 days |
|
| Placebo | Placebo Comparator | Placebo pill manufactured to mimic Rhodiola rosea 200mg, up to four times a day for 28 days |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Rhodiola | Drug | Rhodiola rosea 200mg pill up to four times a day |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in Swanson, Nolan and Pelham Rating Scale - Version IV (SNAP-IV) adapted to adults | Change from baseline SNAP-IV at 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Adult Self-Report Scale (ASRS) | Change from baseline ASRS at 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Wechsler Scale digit subtest (WAIS-III) | Change from baseline WAIS-III at 4 weeks | |
| Change in Stop Signal Task | Change from baseline Stop Signal Task at 4 weeks | |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Eugenio Grevet, PhD | Contact | 55 51 3359-8094 | ehgrevet@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Eugenio Grevet, PhD | Hospital de ClÃnicas de Porto Alegre | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital de ClÃnicas de Porto Alegre | Recruiting | Porto Alegre | Rio Grande do Sul | 90035-903 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 11211365 | Background | Swanson JM, Kraemer HC, Hinshaw SP, Arnold LE, Conners CK, Abikoff HB, Clevenger W, Davies M, Elliott GR, Greenhill LL, Hechtman L, Hoza B, Jensen PS, March JS, Newcorn JH, Owens EB, Pelham WE, Schiller E, Severe JB, Simpson S, Vitiello B, Wells K, Wigal T, Wu M. Clinical relevance of the primary findings of the MTA: success rates based on severity of ADHD and ODD symptoms at the end of treatment. J Am Acad Child Adolesc Psychiatry. 2001 Feb;40(2):168-79. doi: 10.1097/00004583-200102000-00011. | |
| 16411036 |
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| ID | Term |
|---|---|
| D001289 | Attention Deficit Disorder with Hyperactivity |
| ID | Term |
|---|---|
| D019958 | Attention Deficit and Disruptive Behavior Disorders |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
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| Placebo | Drug | up to four times a day |
|
|
| Change in Barkley Side Effect Rating Scale (SERS) |
Including Rhodiola rosea side effects |
| Change from baseline SERS at 4 weeks |
| Change in Insomnia Severity Index (ISI) | Change from baseline ISI at 4 weeks |
| Change in Beck-II Depression Scale | Change from baseline Beck-II Depression Scale at 4 weeks |
| Change in Beck Anxiety Scale | Change from baseline Beck Anxiety Scale at 4 weeks |
| Change in Adult ADHD Quality of Life Questionnaire (AAQoL) | Change from baseline AAQoL at 4 weeks |
| Background |
| Brod M, Johnston J, Able S, Swindle R. Validation of the adult attention-deficit/hyperactivity disorder quality-of-life Scale (AAQoL): a disease-specific quality-of-life measure. Qual Life Res. 2006 Feb;15(1):117-29. doi: 10.1007/s11136-005-8325-z. |
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| 16275215 | Background | Mackin RS, Horner MD. Relationship of the Wender Utah Rating Scale to objective measures of attention. Compr Psychiatry. 2005 Nov-Dec;46(6):468-71. doi: 10.1016/j.comppsych.2005.03.004. |
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