Phenolic-rich Oats and Artery Improvement

Acute Cardiovascular Effects of Phenolic Rich Oats in Men With Above Average Blood Pressure

In this proposed human trial, the investigators aim to establish whether consumption of one portion of phenolic acid-rich oats leads to acute improvements (i.e. 1-24h post-intake) in markers of cardiovascular disease risk relative to an energy matched control intervention in healthy men with high-normal to mildly elevated blood pressure.

A diet rich in whole grain is inversely associated with cardiovascular disease risk. Whole grains contain a wide range dietary components including potentially vasoactive phenolic acids.

Inclusion Criteria:

• Above average blood pressure (i.e. systolic 120-159 mmHg and diastolic 75-99 mmHg)

Exclusion Criteria:

• Abnormal biochemical, haematological results as assessed at health screening
• Hypertension (i.e. systolic/diastolic blood pressure ≥160/100 mm Hg) BMI >35
• Current smoker or ex-smoker ceasing <3 months ago
• Past or existing medical history of vascular disease, diabetes, hepatic, renal, gastrointestinal, haematological, neurological, thyroidal disease or cancer
• Prescribed or taking lipid lowering, antihypertensive, vasoactive (e.g. Viagra), anti-inflammatory, antibiotic or antidepressant medication
• Allergies to whole grains
• Parallel participation in another research project
• Having flu vaccination or antibiotics within 3 months of trial start
• On a weight reduction regime or taking food supplements within 3 months of trial start
• Performing high level of physical activity (i.e. >3 x 20 min aerobic exercise/week)
• Consumption of ≥21 units of alcohol/week
• Small veins not allowing cannulation