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| Name | Class |
|---|---|
| Yunnan Institute For Drug Abuse | UNKNOWN |
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The repetitive transcranial magnetic stimulation (rTMS) will be used to treat amphetamine-type stimulant (ATS) addiction.
The Glutamate and GABA deficits in prefrontal cortex play a vital role in ATS addiction and relapse, and proposed repetitive transcranial magnetic stimulation (rTMS) as a novel interventions. Focused on evaluating Glutamate/GABA functions in prefrontal cortex and functional connectivity with deep brain regions, neuropsychological tests, biochemical tests, magnetic resonance spectroscopy (MRS) and functional MRI will be used to investigate the neurobiological mechanism of ATS addiction and relapse. These methods will also be used to evaluate the efficacy of the novel intervention and investigate the mechanisms. The study will be very helpful to develop novel interventions in clinical practice and decrease ATS-related harm for both the patients and their families.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control group | Sham Comparator | sham repetitive transcranial magnetic stimulation (rTMS) of the left frontal lobe dorsal lateral effect on ATS dependent induced cognitive dysfunction and other symptoms. |
|
| rTMS group | Active Comparator | Use randomized, prospective pseudo stimulus controlled clinical trial design, evaluation of repetitive transcranial magnetic stimulation of the left frontal lobe dorsal lateral effect on ATS dependent induced cognitive dysfunction and other symptoms. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| repetitive transcranial magnetic stimulation (rTMS) | Radiation | Stimulate the dorsomedial prefrontal cortex for 4 weeks by Theta-burst stimulation (TBS), once a day |
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| Measure | Description | Time Frame |
|---|---|---|
| Change from Baseline Craving for ATS assessed by Visual Analog Scales (VAS) at 1 month | evaluate all participants' craving for ATS by Visual Analog Scales (VAS) | Baseline and 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants who relapse | Follow up with patients after discharge, evaluate number of participants who relapse | 1 month |
| Depression status assessed by Patient Health Questionnaire-9(PHQ-9) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Zhao Min, PhD | Shanghai Mental Health Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shanghai Gaojing Rehabilitation Center | Shanghai | Shanghai Municipality | 201900 | China |
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| ID | Term |
|---|---|
| D019969 | Amphetamine-Related Disorders |
| ID | Term |
|---|---|
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D050781 | Transcranial Magnetic Stimulation |
| ID | Term |
|---|---|
| D055909 | Magnetic Field Therapy |
| D013812 | Therapeutics |
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| sham repetitive transcranial magnetic stimulation (rTMS) | Radiation | Stimulate the dorsomedial prefrontal cortex for 4 weeks by sham Theta-burst stimulation (TBS), once a day |
|
evaluate all participants' depression status by Patient Health Questionnaire-9(PHQ-9)
| 1 month |
| Anxiety status assessed by Generalized Anxiety Disorder Screener (GAD-7) | evaluate all participants' anxiety status by Generalized Anxiety Disorder Screener (GAD-7) | 1 month |
| Cognitive function assessed by Cogstate Battery | evaluate all participants' cognition by Cogstate Battery Chinese version | 1 month |
| Functional connectivity assessed by MRI | evaluate all participants' functional connectivity in the brain by MRI | 1 month |