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The purpose of this study is to determine whether Propofol and Sevoflurane affect the oxidative stress and apoptosis status in children undergoing hypospadias repair surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sevoflurane General anesthesia | Experimental | Anesthesia was induced with 8% sevoflurane with 8L/min oxygen. Anesthesia was maintained with 1-3% sevoflurane in oxygen/air mixture. |
|
| Propofol General anesthesia | Experimental | Anesthesia was induced with propofol 4mg/kg. Anesthesia was maintained with propofol 7-12mg/kg/h. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sevoflurane | Drug |
| ||
| Propofol |
| Measure | Description | Time Frame |
|---|---|---|
| the change of blood glutathione peroxidase(GPx) level in perioperative period | immediately after anesthetic induction, 2h and 3 days after operation | |
| the change of blood-separated erythrocytes superoxide dismutase (SOD) activities in perioperative period | the blood sample was separated and erythrocytes was obtained, superoxide dismutase activity was measured using a commercially available assay-Ransod kit (Randox Laboratories, UK). | immediately after anesthetic induction, 2h and 3 days after operation |
| the change of blood-separated erythrocytes catalase (CAT) activities in perioperative period | the blood sample was separated and erythrocytes was obtained, catalase activity was measured using the OxiSelect catalase activity assay (Cell Biolabs, San Diego, CA, USA) | immediately after anesthetic induction, 2h and 3 days after operation |
| the change of blood-separated lymphocytes caspase-3 mRNA level in perioperative period | Lymphocytes were separated from whole blood and freshly used for real-time PCR of caspase-3 | immediately after anesthetic induction, 2h and 3 days after operation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Xue Zhou, Master | Department of Anesthesiology, the First-Affiliated Hospital of Sun Yat-Sen University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The First Affiliated Hospital of Sun Yat-Sen University | Guangzhou | Guangdong | 510080 | China |
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| ID | Term |
|---|---|
| D000077149 | Sevoflurane |
| D015742 | Propofol |
| ID | Term |
|---|---|
| D008738 | Methyl Ethers |
| D004987 | Ethers |
| D009930 | Organic Chemicals |
| D006845 | Hydrocarbons, Fluorinated |
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|
| D006846 |
| Hydrocarbons, Halogenated |
| D006838 | Hydrocarbons |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |