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The aim of the study is to compare the efficacy and safety of low-dose combination of three antihypertensive drugs versus fixed high-dose combination of two antihypertensive drugs in arterial hypertension
The aim of the study is to compare the efficacy and safety of commercially available low-dose combination of three antihypertensive drugs versus commercially available fixed high-dose combination of two antihypertensive drugs in arterial hypertension
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Three antihypertensive Drugs | Active Comparator | Patients will be treated with Tripliam, that is a commercially available fixed low-dose combination of three antihypertensive drugs, that is 5 mg/daily perindopril, 1,25 mg/daily indapamide and 5 mg/day amlodipine |
|
| Two antihypertensive drugs | Active Comparator | Patients will be treated with Reaptan, that is a commercially available fixed high-dose combination of two antihypertensive drugs, that is 10 mg/daily perindopril and 5 mg/day amlodipine |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tripliam (perindopril, indapamide, amlodipine) | Drug | Fixed combination of perindopril 5 mg, indapamide 1,25 and amlodipine 5 mg |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of patients who reach target blood pressure | How many patients have blood pressure within normal limits | From baseline to the end of the 3-month study period |
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Inclusion Criteria:
Patients with arterial hypertension resistant to monotherapy
Exclusion Criteria:
None
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Francesco Pelliccia, MD | Contact | 390649971 | 123 | md4151@mclink.it |
| Cesare Greco, MD | Contact | 390649971 | 123 | md4151@mclink.it |
| Name | Affiliation | Role |
|---|---|---|
| Carlo Gaudio, MD | Sapienza University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sapienza University | Rome | 00161 | Italy |
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| ID | Term |
|---|---|
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D020913 | Perindopril |
| D007190 | Indapamide |
| D017311 | Amlodipine |
| ID | Term |
|---|---|
| D007211 | Indoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
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| Reaptan (perindopril, amlodipine) | Drug | Fixed combination of perindopril 10 mg and amlodipine 5 mg |
|
|
| D013449 | Sulfonamides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D013450 | Sulfones |
| D013457 | Sulfur Compounds |
| D004095 | Dihydropyridines |
| D011725 | Pyridines |
| D006573 | Heterocyclic Compounds, 1-Ring |