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Randomized comparison of once-daily fixed combiNation versus free-drug combination of three antihypertensive agents in arterial hypertension
The aim of this randomized study is to compare a once-daily fixed combination pill with a free-drug combination of three antihypertensive agents in arterial hypertension
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Free combination | Active Comparator | Perindopril 10 mg/daily, indapamide 2,5 mg/daily, and amlodipine 10 mg/daily will be given according to a free combination strategy |
|
| Tripliam | Active Comparator | fixed combination of perindopril 10 mg/daily, indapamide 2,5 mg/daily, amlodipine 10 mg/daily |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| perindopril, indapamide , amlodipine | Drug | Free combination of perindopril 10 mg, indapamide 2,5 mg, amlodipine 10 mg |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of patients who reach target blood pressure | How many patients have blood pressure within normal limits | From baseline to the end of the 3-month study period |
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Inclusion Criteria:
Patients with arterial hypertension resistant to monotherapy
Exclusion Criteria:
None
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Francesco Pelliccia, MD | Contact | +39064997 | 123 | f.pelliccia@mclink.it |
| Cesare Greco, MD | Contact | +39064997 | 123 | md4151@mclink.it |
| Name | Affiliation | Role |
|---|---|---|
| Carlo Gaudio, MD | Sapienza University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University La Sapienza | Rome | 00166 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27522394 | Derived | Marazzi G, Pelliccia F, Campolongo G, Cacciotti L, Massaro R, Poggi S, Tanzilli A, Di Iorio M, Volterrani M, Lainscak M, Rosano GM. Greater cardiovascular risk reduction with once-daily fixed combination of three antihypertensive agents and statin versus free-drug combination: The ALL-IN-ONE trial. Int J Cardiol. 2016 Nov 1;222:885-887. doi: 10.1016/j.ijcard.2016.07.163. Epub 2016 Jul 29. |
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| ID | Term |
|---|---|
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D020913 | Perindopril |
| D007190 | Indapamide |
| D017311 | Amlodipine |
| ID | Term |
|---|---|
| D007211 | Indoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
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| Tripliam (perindopril, indapamide, amlodipine) | Drug | Fixed combination of perindopril 10 mg, indapamide 2,5 mg, amlodipine 10 mg |
|
|
| D013449 | Sulfonamides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D013450 | Sulfones |
| D013457 | Sulfur Compounds |
| D004095 | Dihydropyridines |
| D011725 | Pyridines |
| D006573 | Heterocyclic Compounds, 1-Ring |