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The goal of this project is to evaluate the influence of platelet rich fibrin (PRF) in extraction socket healing with or without particulate bone graft. The hypothesis of this study is that PRF will enhance the extraction socket healing and new bone formation when compared to extraction sockets grafted without PRF.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| No socket grafting | No Intervention | Extraction with normal socket healing | |
| Socket grafting with platelet rich fibrin (PRF) alone | Active Comparator | Extraction with socket grafting with platelet rich fibrin (PRF) alone. |
|
| Socket grafting with bone grafting alone | Active Comparator | Extraction with socket grafting using bone graft (xenograft). |
|
| Socket grafting with PRF and bone grafting | Active Comparator | Extraction with socket grafting using PRF combined with bone graft (xenograft). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Socket grafting with PRF | Procedure | Extraction with socket grafting using PRF. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in alveolar ridge width (buccal-lingual) | Baseline is at the time of extraction with or without socket grafting. | baseline, 3 months |
| Change in alveolar ridge height (apical coronal) | Baseline is at the time of extraction with or without socket grafting. | baseline, 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of vital bone in bone core as assessed histology | A bone core will be taken at 3 months after socket grafting. | 3 months |
| Percentage of residual bone graft in bone core as assessed histology |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sridhar Eswaran, BDS, MS, MSD | The University of Texas Health Science Center, Houston | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The University of Texas Health Science Center at Houston School of Dentistry | Houston | Texas | 77030 | United States |
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| Socket grafting with bone graft | Procedure | Extraction with socket grafting using bone graft. |
|
A bone core will be taken at 3 months after socket grafting.
| 3 months |
| ID | Term |
|---|---|
| D056690 | Prolactin-Releasing Hormone |
| D016025 | Bone Transplantation |
| ID | Term |
|---|---|
| D007028 | Hypothalamic Hormones |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D009479 | Neuropeptides |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D009419 | Nerve Tissue Proteins |
| D011506 | Proteins |
| D016378 | Tissue Transplantation |
| D064987 | Cell- and Tissue-Based Therapy |
| D001691 | Biological Therapy |
| D013812 | Therapeutics |
| D019637 | Orthopedic Procedures |
| D013514 | Surgical Procedures, Operative |
| D014180 | Transplantation |
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