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The purpose of this study is to determine the prevalence of positive antiphospholipid antibodies among women with preeclampsia and to determine the effect of antiphospholipid antibodies on the severity of preeclampsia and the obstetric outcomes
For all women included in the study, blood samples will be tested for anticardiolipin antibodies and lupus anticoagulant. The clinical details of all women will be collected by reviewing their hospital and prenatal records. The following clinical characteristics will be evaluated: maternal age, previous gestations, parity, past or family history of preeclampsia, gestational age at the onset of preeclampsia, gestational age at delivery and birth weight. The following pregnancy and delivery complications will be assessed: placental insufficiency, intrauterine growth restriction, fetal loss (stillbirth) and early neonatal death.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pregnant women with preeclampsia | Testing for antiphospholipid antibodies (anticardiolipin antibodies and lupus anticoagulant) will be performed in pregnant women with preeclampsia. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Testing for antiphospholipid antibodies | Other | Blood samples will be tested for anticardiolipin antibodies and lupus anticoagulant |
|
| Measure | Description | Time Frame |
|---|---|---|
| Rate of positive antiphospholipid antibodies | Number of women having positive antiphospholipid antibodies per total number of women | 20 weeks to 42 weeks gestational age |
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Inclusion Criteria:
Exclusion Criteria:
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Attendants of Tertiary Hospital Obstetric Outpateint Clinics and Emergency Department
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| Name | Affiliation | Role |
|---|---|---|
| Hanaa M El-Shafiey | Mansoura University | Principal Investigator |
| Mohamed S Abdelhafez, Dr | Mansoura University | Study Director |
| Alaa El-Din M El-Gohary, Dr | Mansoura University | Study Director |
| El-Said M Abd El-Hady, Prof | Mansoura University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Obstetrics and Gynecology Department in Mansoura University Hospital | Al Mansurah | Dakahlia Governorate | 35111 | Egypt |
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| ID | Term |
|---|---|
| D011225 | Pre-Eclampsia |
| ID | Term |
|---|---|
| D046110 | Hypertension, Pregnancy-Induced |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D017152 | Antibodies, Antiphospholipid |
| ID | Term |
|---|---|
| D001323 | Autoantibodies |
| D000906 | Antibodies |
| D007136 | Immunoglobulins |
| D007162 | Immunoproteins |
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Blood samples will be tested for anticardiolipin antibodies and lupus anticoagulant
| D001798 |
| Blood Proteins |
| D011506 | Proteins |
| D000602 | Amino Acids, Peptides, and Proteins |
| D012712 | Serum Globulins |
| D005916 | Globulins |