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To evaluate the impact of obesity surgery on chronic inflammation.
A retrospective study to compare the impact of laparoscopic sleeve gastrectomy (LSG), laparoscopic Roux-en Y- gastric bypass (LRYGB) and laparoscopic omega-loop gastric bypass (LOLGB) on chronic inflammation and metabolic syndrome.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| laparoscopic sleeve gastrectomy | patients who underwent laparoscopic sleeve gastrectomy (LSG) due to obesity and/or metabolic syndrome |
| |
| laparoscopic Roux-en-Y- gastric bypass | patients who underwent laparoscopic Roux-en-Y- gastric bypass (LRYGB) due to obesity and/or metabolic syndrome |
| |
| laparoscopic omega-loop gastric bypass | patients who underwent laparoscopic omega-loop gastric bypass (LOLGB) due to obesity and/or metabolic syndrome |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Laboratory Examination | Other | Laboratory Examination before, 1 month, 3 month, 6 month and up to 12 month after LSK, LRNYGB, LOLGB |
|
| Measure | Description | Time Frame |
|---|---|---|
| Chronic inflammation | the changing of leucocytes in /nl after obesity surgery | one day preoperatively, and 1 month, 3 month, 6 month and up to 12 month postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| Fatty liver index | the changing of fatty liver index after obesity surgery | one day preoperatively and 1 month, 3 month, 6 month and up to 12 month postoperatively |
| Liver enzymes | the changing of GOT in U/l, GPT in U/l, GGT in U/l, AP in U/l after obesity surgery |
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Inclusion Criteria:
Exclusion Criteria:
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Patients who underwent LSG, LRYGB, LOLGB due to obesity and/or metabolic syndrome
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| Name | Affiliation | Role |
|---|---|---|
| Rudolf Weiner, MD | Sana Klinikum Offenbach, Department of Obesity and Metabolic Surgery | Study Chair |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17167474 | Result | Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006 Dec 14;444(7121):860-7. doi: 10.1038/nature05485. | |
| 19390527 | Result | Nijhuis J, Rensen SS, Slaats Y, van Dielen FM, Buurman WA, Greve JW. Neutrophil activation in morbid obesity, chronic activation of acute inflammation. Obesity (Silver Spring). 2009 Nov;17(11):2014-8. doi: 10.1038/oby.2009.113. Epub 2009 Apr 23. |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| one day preoperatively and 1 month, 3 month, 6 month and up to 12 month postoperatively |
| Body Mass Index (BMI) in kg/m² | the changing of BMI in kg/m² before and after obesity surgery | one day preoperatively and 1 month, 3 month, 6 month and up to 12 month postoperatively |
| weight in kg | the changing of weight before and after obesity surgery | one day preoperatively and 1 month, 3 month, 6 month and up to 12 month postoperatively |
| waist circumference | the changing of waist circumference in cm before and after obesity surgery | one day preoperatively and 1 month, 3 month, 6 month and up to 12 month postoperatively |
| HbA1c | the changing of HbA1c in % and after obesity surgery | one day preoperatively and 1 month, 3 month, 6 month and up to 12 month postoperatively |
| Chronic inflammation II | the changing of c-reactive protein in mg/l after obesity surgery | one day preoperatively and 1 month, 3 month, 6 month and up to 12 month postoperatively |
| Acute inflammation | the changing of c-reactive protein in mg/l after obesity surgery | one day preoperatively and one and four days postoperatively |
| Acute inflammation II | the changing of leucocytes in /nl after obesity surgery | one day preoperatively and one and four days postoperatively |
| 26865887 | Result | Morshed G, Fathy SM. Impact of post-laparoscopic sleeve gastrectomy weight loss on C-reactive protein, lipid profile and CA-125 in morbidly obese women. Wideochir Inne Tech Maloinwazyjne. 2016 Jan;10(4):521-6. doi: 10.5114/wiitm.2015.56480. Epub 2015 Dec 15. |
| 15864338 | Result | Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. J Clin Invest. 2005 May;115(5):1111-9. doi: 10.1172/JCI25102. |
| 15599400 | Result | Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, Nakayama O, Makishima M, Matsuda M, Shimomura I. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest. 2004 Dec;114(12):1752-61. doi: 10.1172/JCI21625. |
| 29876839 | Derived | Chiappetta S, Schaack HM, Wolnerhannsen B, Stier C, Squillante S, Weiner RA. The Impact of Obesity and Metabolic Surgery on Chronic Inflammation. Obes Surg. 2018 Oct;28(10):3028-3040. doi: 10.1007/s11695-018-3320-y. |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |