Impact of Bariatric Surgery on Nonalcoholic Fatty Liver Disease

The Impact of Bariatric Surgery on Nonalcoholic Fatty Liver Disease and Cardiovascular Risk Utilizing Non-invasive Measures

The purpose of this study is to investigate the effect of weight loss rate on liver steatosis, steatohepatitis, fibrosis and cardiovascular risk at different stages before and after bariatric surgery. The investigators also aim to study the short-term effect of bariatric surgery on gastric cholecystokinin levels before and 10 days after the bariatric surgery.

Inclusion Criteria:

• 20≤ age ≤80
• BMI>35kg/m2
• Men and women
• Fatty infiltration in liver ultrasonography

Exclusion Criteria:

• Alcohol drinking > 140g/week

• Presence of hepatitis B or C or HIV

• Known liver disease such as:

  1. Wilson's disease
  2. hemochromatosis
  3. α1-antitrypsin deficiency
  4. autoimmune liver disease
  5. primary biliary cirrhosis
  6. primary sclerosing cholangitis)