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Sepsis is still a challenge for clinicians since the detailed pathomechanism are still unknown and until now early markers for sepsis are not defined yet. Immunological pathways and new mediators defined in animal models are not yet investigated in patients with sepsis. Therefore the investigators will measure new mediators in patients with septic shock.
Semaphorins 1 to 7 will be determined in Blood of patients with early septic shock. Concentration will be compared with blood concentration of postoperative patients suffering systemic inflammatory response syndrome (SIRS).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| sepsis | Patients with septic shock admitted to ICU |
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| Measure | Description | Time Frame |
|---|---|---|
| Semaphorin 1 to 7 in plasma of septic patients | Concentration of Semaphorin in plasma of 60 sepsis patients [pg/ml]. | 12 months |
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Inclusion Criteria:
Exclusion Criteria:
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Intensive Care patients with septic shock
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Peter Rosenberger, MD | Contact | +49(0)7071298 | 6622 | peter.rosenberger@med.uni-tuebingen.de |
| Helene A Haeberle, MD | Contact | +49(0)7071298 | 6622 | helene.haeberle@med.uni-tuebingen.de |
| Name | Affiliation | Role |
|---|---|---|
| Peter Rosenberger, MD | University Hospital Tuebingen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Tuebingen | Recruiting | Tübingen | 72076 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38489236 | Derived | Granja T, Kohler D, Tang L, Burkard P, Eggstein C, Hemmen K, Heinze KG, Heck-Swain KL, Koeppen M, Gunther S, Blaha M, Magunia H, Bamberg M, Konrad F, Ngamsri KC, Fuhr A, Keller M, Bernard AM, Haeberle HA, Bakchoul T, Zarbock A, Nieswandt B, Rosenberger P. Semaphorin 7A coordinates neutrophil response during pulmonary inflammation and sepsis. Blood Adv. 2024 Jun 11;8(11):2660-2674. doi: 10.1182/bloodadvances.2023011778. |
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| ID | Term |
|---|---|
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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Blood samples