Inflammatory Mediators in Early Sepsis

Inflammatory Mediators in Sepsis as Indicator for Infection vs Inflammation

Sepsis is still a challenge for clinicians since the detailed pathomechanism are still unknown and until now early markers for sepsis are not defined yet. Immunological pathways and new mediators defined in animal models are not yet investigated in patients with sepsis. Therefore the investigators will measure new mediators in patients with septic shock.

Semaphorins 1 to 7 will be determined in Blood of patients with early septic shock. Concentration will be compared with blood concentration of postoperative patients suffering systemic inflammatory response syndrome (SIRS).

Inclusion Criteria:

• Septic Shock

Exclusion Criteria:

• Age < 18 > 85
• no consent of caregiver
• Trauma patients
• Burn patients
• Immunosuppression
• Pregnancy
• HIV- hepatitis infection