Mediators of Inflammation, Prognostic Markers and Genetic Polymorphisms in Patients With Sepsis

Evaluation of Mediators of Inflammation, Prognostic Markers and Genetic Polymorphisms in Patients With Sepsis

During the past years many investigators have focused on the immunological changes in sepsis disease, and great attention has been paid to the development of practicable means of immunomonitoring. Little is known about diagnostic and prognostic vascular biomarkers during the time course of patients with sepsis.

Primary Outcome Measures:

New diagnostic and prognostic markers for septic patients

Estimated Enrollment: 300 patients Study Start Date: January 2012 Estimated Study Completion Date: open Estimated Primary Completion Date: open

Intervention Details:

Procedure: vein puncture comparison of different inflammatory markers in the blood of septic patients

Inclusion Criteria:

• SIRS-Criteria
• Proven Infection
• One sepsis-induced organ-failure
• Adults < 18 years old

Exclusion Criteria:

• Anemia
• Pregnancy
• Blood donor in the last 3 month