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Intussusception is one of the most frequent causes of acute bowel and second most common cause of acute abdominal pain in pediatric age .95 % of cases are idiopathic, the rest are either due to pathological lead point or post operative. Treatment of intussusception must start with medical resuscitation, then radiological or operative reduction of intussusception.
Our surgery team has used hydrocortisone with the medical resuscitation to improve the success rate of pneumatic reduction and decrease the number of reduction trials.
Experimental group will be given single dose IV Hydrocortisone 10 mg/kg with Resuscitation before attempting first trial of pneumatic reduction and the outcome measured.
Control group will be given Saline 100 ml IV single injection with Resuscitation before attempting first trial of pneumatic reduction and the outcome measured.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hydrocortisone | Experimental | Hydrocortisone IV 10 mg/kg with Resuscitation before attempting reduction, single dose with Resuscitation before attempting reduction |
|
| Saline | Placebo Comparator | Saline IV 100 ml with Resuscitation before attempting reduction, single dose with Resuscitation before attempting reduction |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hydrocortisone | Drug | 10 mg/kg with Resuscitation before attempting pneumatic reduction, single dose with Resuscitation before attempting reduction |
|
| Measure | Description | Time Frame |
|---|---|---|
| Success of Pneumatic Reduction | Comparing number of Successful Pneumatic Reductions in both groups | 1 Hour |
| Measure | Description | Time Frame |
|---|---|---|
| Reducing number of trials of Pneumatic Reduction | Comparing average number of Pneumatic Reduction trials between both groups | 2 Hours |
| Reducing complications | Comparing number of complications in both groups |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mostafa Gad, MSc | Contact | 201002265009 | mostafagad@kasralainy.edu.eg | |
| Mahmoud Elfiky, MD | Contact | 201001557755 | mfiky@kasralainy.edu.eg |
| Name | Affiliation | Role |
|---|---|---|
| Gamal El Tagy, MD | Cairo University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cairo University Pediatric Hospital | Recruiting | Cairo | 11432 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Background | Gersema, Lisa, and Karen Baker. | ||
| Result | Kara, Cüneyt Orhan, and Inci Gökalan. |
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| ID | Term |
|---|---|
| D007443 | Intussusception |
| ID | Term |
|---|---|
| D007415 | Intestinal Obstruction |
| D007410 | Intestinal Diseases |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
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| ID | Term |
|---|---|
| D006854 | Hydrocortisone |
| C007133 | hydrocortisone hemisuccinate |
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D011282 | Pregnenediones |
| D011283 | Pregnenes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 |
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| Saline | Drug | 100 ml with Resuscitation before attempting pneumatic reduction, single dose with Resuscitation before attempting reduction |
|
|
| 2 Hours |
| Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D015062 | 11-Hydroxycorticosteroids |
| D006889 | Hydroxycorticosteroids |
| D000305 | Adrenal Cortex Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D015065 | 17-Hydroxycorticosteroids |
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017670 | Sodium Compounds |