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| ID | Type | Description | Link |
|---|---|---|---|
| Afssaps: 060785 | |||
| CPP: 2006/25 |
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| Name | Class |
|---|---|
| Serb | UNKNOWN |
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Interest of treatment of polytraumatisms with corticoids (hydrocortisone) for patient with relative adrenocortical insufficiency on frequency of nosocomial infection, and hemodynamic complications and organs injuries.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| H | Experimental | Hydrocortisone |
|
| P | Placebo Comparator | Treatment by NaCl (placebo) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| hydrocortisone | Drug | 200mg/jour (solution of 48mL), Day 1 to Day 4 100mg/jour (solution of 48mL), Day 5 50mg/jour (solution of 48mL), Day 6 |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of nosocomial pneumopathy: radiological, clinical and bacteriological criteria | 28 days |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of bacteremia, urinary infections, infections of the operatory sites, incidence of SDRA, organ dysfunction,mortality, etc. | 28 days | |
| Incidence of nosocomial pneumopathy | Day 8 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mahe Joachim, MD | Nantes University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Bordeaux | Bordeaux | France | ||||
| CHU Morvan de Brest |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23450051 | Derived | Le Bras M, Roquilly A, Deckert V, Langhi C, Feuillet F, Sebille V, Mahe PJ, Bach K, Masson D, Lagrost L, Costet P, Asehnoune K, Cariou B. Plasma PCSK9 is a late biomarker of severity in patients with severe trauma injury. J Clin Endocrinol Metab. 2013 Apr;98(4):E732-6. doi: 10.1210/jc.2012-4236. Epub 2013 Feb 28. | |
| 22777514 | Derived |
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| ID | Term |
|---|---|
| D009104 | Multiple Trauma |
| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
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| ID | Term |
|---|---|
| D006854 | Hydrocortisone |
| ID | Term |
|---|---|
| D011282 | Pregnenediones |
| D011283 | Pregnenes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 |
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| NaCl | Drug | 48mL from Day 1 to Day 6 |
|
| Brest |
| 29609 |
| France |
| CHU Caen | Caen | France |
| CH La Roche Sur Yon | La Roche-sur-Yon | France |
| Hôtel Dieu | Nantes | 44093 | France |
| CHU Pontchaillou | Rennes | 35033 | France |
| CHU Trousseau | Tours | 37044 | France |
| Asehnoune K, Mahe PJ, Seguin P, Jaber S, Jung B, Guitton C, Chatel-Josse N, Subileau A, Tellier AC, Masson F, Renard B, Malledant Y, Lejus C, Volteau C, Sebille V, Roquilly A. Etomidate increases susceptibility to pneumonia in trauma patients. Intensive Care Med. 2012 Oct;38(10):1673-82. doi: 10.1007/s00134-012-2619-8. Epub 2012 Jul 10. |
| 21427372 | Derived | Roquilly A, Mahe PJ, Seguin P, Guitton C, Floch H, Tellier AC, Merson L, Renard B, Malledant Y, Flet L, Sebille V, Volteau C, Masson D, Nguyen JM, Lejus C, Asehnoune K. Hydrocortisone therapy for patients with multiple trauma: the randomized controlled HYPOLYTE study. JAMA. 2011 Mar 23;305(12):1201-9. doi: 10.1001/jama.2011.360. |
| Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D015062 | 11-Hydroxycorticosteroids |
| D006889 | Hydroxycorticosteroids |
| D000305 | Adrenal Cortex Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D015065 | 17-Hydroxycorticosteroids |