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The aim of the study is to determine the total concentration of HCMV- and VZV-specific IgG-antibodies and the total concentration of neutralizing antibodies against HCMV in neonatal bloodstream depending on gestational age at birth.
For data gathering the investigators measure the main concentration of specific HCMV-/VZV-IgG-antibodies and the concentration of neutralizing IgG-antibodies against HCMV and VZV in maternal blood and in fetal bloodstream. Then the investigators compare the data of mother and newborn. Therefore, the investigators use the following blood samples:
Mother: Venous blood sample taken at birth (+/- three days)
Newborn: Blood sample of umbilical cord (= fetal bloodstream) taken immediately after birth.
The investigators assign the data of each newborn (gestational age at birth) to the data of their respective mother for statistical evaluation. After finishing the study the investigators will destroy all residual blood.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HCMV antibody-transfer | Materno-fetal HCMV antibody-Transfer form 24-41 weeks of gestation |
| |
| VZV antibody-transfer | Materno-fetal VZV antibody-Transfer form 24-41 weeks of gestation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood samples | Other | Taking blood form the umbilical cord (fetal circulation) and from the vein of the corresponding mother. |
|
| Measure | Description | Time Frame |
|---|---|---|
| To measure the concentration of specific HCMV-/VZV-IgG-antibodies in fetal bloodstream depending on gestational age at birth. | Measurement of HCMV and VZV-antibodies in the fetal and the maternal circulation | Newborn: immediately after birth; Mother +/- 3 days at birth |
| Measure | Description | Time Frame |
|---|---|---|
| Gauging the concentration of neutralizing IgG-antibodies against HCMV and VZV in fetal bloodstream depending on gestational age at birth. | Measurement of neutralizing IgG-HCMV and VZV-antibodies in the fetal and the maternal circulation | Newborn: immediately after birth; Mother +/- 3 days at birth |
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Inclusion Criteria:
Exclusion Criteria:
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Approximately 450 mother-child-pairs seropositive for HCMV and/or VZV
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Horst Buxmann, PI | Contact | +49 69 6301 | 5524 | horst.buxmann@kgu.de |
| Clara A Lüdeke, SI | Contact | +49 17662403039 | clara.luedeke@web.de |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clinic of the Johann Wolfgang-Goethe Univeristy | Recruiting | Frankfurt am Main | Hesse | 60590 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 4164125 | Result | Hobbs JR, Davis JA. Serum gamma-G-globulin levels and gestational age in premature babies. Lancet. 1967 Apr 8;1(7493):757-9. doi: 10.1016/s0140-6736(67)91369-4. No abstract available. | |
| 12850341 | Result | Simister NE. Placental transport of immunoglobulin G. Vaccine. 2003 Jul 28;21(24):3365-9. doi: 10.1016/s0264-410x(03)00334-7. |
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Umbilical Cord blood; Blood from peripheral vene
| 12683413 | Result | Mussi-Pinhata MM, Pinto PC, Yamamoto AY, Berencsi K, de Souza CB, Andrea M, Duarte G, Jorge SM. Placental transfer of naturally acquired, maternal cytomegalovirus antibodies in term and preterm neonates. J Med Virol. 2003 Feb;69(2):232-9. doi: 10.1002/jmv.10271. |
| 10891827 | Result | Linder N, Waintraub I, Smetana Z, Barzilai A, Lubin D, Mendelson E, Sirota L. Placental transfer and decay of varicella-zoster virus antibodies in preterm infants. J Pediatr. 2000 Jul;137(1):85-9. doi: 10.1067/mpd.2000.106902. |
| ID | Term |
|---|---|
| D002644 | Chickenpox |
| ID | Term |
|---|---|
| D000073618 | Varicella Zoster Virus Infection |
| D006566 | Herpesviridae Infections |
| D004266 | DNA Virus Infections |
| D014777 | Virus Diseases |
| D007239 | Infections |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
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