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The aim of this single centre study is to measure maternal CD4+ t-cells in HiV exposed Newborns after spontaneous birth in comparison to cesarean section.
This may have an influence on the risk of vertical HiV transmission.
At birth maternal CD4+ t-cells from umbilical cord blood and placenta blood are measured by microchimerism-analysis.
After 6 weeks the maternal CD4+ t-cells are measured in the blood of the babies blood.
Additionally we look for HiV in maternal CD4+ t-cells.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Spontaneous delivery | Approximately 15 HiV exposed Newborns with low HiV transmission risk, born via spontaneous delivery. | ||
| Cesarean section | Approximately 15 HiV exposed Newborns with low HiV transmission risk, born via cesarean section. |
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| Measure | Description | Time Frame |
|---|---|---|
| Maternal CD4+ t-cells in HiV exposed Newborns | The maternal CD4+ t-cells are measured by microchimersimanalysis | Six weeks after date of birth |
| Measure | Description | Time Frame |
|---|---|---|
| HiV transmission rate | Measurement of HiV PCR at the age of 6 month after birth | 6 month after birth |
| Analysis of HiV in maternal CD4+ t-cells | HiV-PCR analysis from maternal CD4+ cells |
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Inclusion Criteria:
• HiV exposed Newborns with normal risk of HiV transmission.
Exclusion Criteria:
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Approximately 30 HiV exposed newborns born via spontaneuous delivery or cesarean section.
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| Name | Affiliation | Role |
|---|---|---|
| Horst Buxmann, Dr. med. | Johann Wolfgang Goethe University Hospital Frankfurt/Main, Department of Neonatology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clinic of the Johann Wolfgang-Goethe Univeristy | Frankfurt am Main | Hesse | 60590 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20059573 | Background | European Collaborative Study; Boer K, England K, Godfried MH, Thorne C. Mode of delivery in HIV-infected pregnant women and prevention of mother-to-child transmission: changing practices in Western Europe. HIV Med. 2010 Jul 1;11(6):368-78. doi: 10.1111/j.1468-1293.2009.00800.x. Epub 2010 Jan 4. | |
| 19172555 | Background |
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| ID | Term |
|---|---|
| D000163 | Acquired Immunodeficiency Syndrome |
| ID | Term |
|---|---|
| D015658 | HIV Infections |
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
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Umbilical Cord blood Blood from peripheral vene
| 2 month after delivery |
| Measurement of maternal CD8+ t-cells in the Newborn | Measurement of maternal CD8+ t-cells by microchimerismanalysis | 6 weeks |
| Gemeinsame Erklarung* der Deutschen AIDS-Gesellschaft (DAIG); Osterreichischen AIDS-Gesellschaft (OAG); Kompetenznetzes HIV/AIDS sowie des Robert-Koch-Institutes Berlin (RKI); Deutschen Arbeitsgemeinschaft niederniedergelassener Arzte in der Versorgung von HIV-und AIDS-Patienten (DAGNA); Deutschen Gesellschaft fur Kinderheilkunde und Jugendmedizin (DGKJ); Padiatrischen Arbeitsgemeinschaft AIDS Deutschland (PAAD); Deutschen Gesellschaft fur Gynakologie und Geburtshilfe (DGGG); Nationalen Referenzzentrums fur Retroviren (NRZ) der Deutschen AIDS-Hilfe (DAH). [German-Austrian recommendations for HIV treatment during pregnancy and for newborns exposed to HIV--Update 2008]. Dtsch Med Wochenschr. 2009 Jan;134 Suppl 1:S40-54. doi: 10.1055/s-0028-1123974. Epub 2009 Jan 26. No abstract available. German. |
| 17984038 | Background | Willasch A, Schneider G, Reincke BS, Shayegi N, Kreyenberg H, Kuci S, Weber G, Van Der Reijden B, Niethammer D, Klingebiel T, Bader P. Sequence polymorphism systems for quantitative real-time polymerase chain reaction to characterize hematopoietic chimerism-high informativity and sensitivity as well as excellent reproducibility and precision of measurement. Lab Hematol. 2007;13(3):73-84. |
| D015229 |
| Sexually Transmitted Diseases, Viral |
| D012749 | Sexually Transmitted Diseases |
| D016180 | Lentivirus Infections |
| D012192 | Retroviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D012897 | Slow Virus Diseases |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D007153 | Immunologic Deficiency Syndromes |
| D007154 | Immune System Diseases |